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dc.contributor.authorLarsen, Brendan B
dc.contributor.authorCole, Kenneth L
dc.contributor.authorWorobey, Michael
dc.date.accessioned2018-09-24T20:50:06Z
dc.date.available2018-09-24T20:50:06Z
dc.date.issued2018-01
dc.identifier.citationBrendan B Larsen, Kenneth L Cole, Michael Worobey; Ancient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodents, Virus Evolution, Volume 4, Issue 1, 1 January 2018, vey014, https://doi.org/10.1093/ve/vey014en_US
dc.identifier.issn2057-1577
dc.identifier.pmid29977605
dc.identifier.doi10.1093/ve/vey014
dc.identifier.urihttp://hdl.handle.net/10150/629141
dc.description.abstractThe long-term evolutionary history of many viral lineages is poorly understood. Novel sources of ancient DNA combined with phylogenetic analyses can provide insight into the time scale of virus evolution. Here we report viral sequences from ancient North American packrat middens. We screened samples up to 27,000-years old and found evidence of papillomavirus (PV) infection in Neotoma cinerea (Bushy-tailed packrat). Phylogenetic analysis placed the PV sequences in a clade with other previously published PV sequences isolated from rodents. Concordance between the host and virus tree topologies along with a correlation in branch lengths suggests a shared evolutionary history between rodents and PVs. Based on host divergence times, PVs have likely been circulating in rodents for at least 17 million years. These results have implications for our understanding of PV evolution and for further research with ancient DNA from Neotoma middens.en_US
dc.description.sponsorshipNational Science Foundation [DGE-1143953]; David and Lucile Packard Foundationen_US
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.urlhttps://academic.oup.com/ve/article/doi/10.1093/ve/vey014/5039640en_US
dc.rights© The Author(s) 2018. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.subjectpaleovirologyen_US
dc.subjectpapillomavirusen_US
dc.subjectrodenten_US
dc.subjectancient DNAen_US
dc.titleAncient DNA provides evidence of 27,000-year-old papillomavirus infection and long-term codivergence with rodentsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Ecol & Evolutionary Biolen_US
dc.identifier.journalVIRUS EVOLUTIONen_US
dc.description.noteOpen Access Journal.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleVirus Evolution
dc.source.volume4
dc.source.issue1
refterms.dateFOA2018-09-24T20:50:07Z


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