• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    molecules-23-01418.pdf
    Size:
    969.7Kb
    Format:
    PDF
    Description:
    Final Published version
    Download
    Author
    Stivers, Nicole
    Islam, Ashraful
    Reyes-Reyes, Elsa
    Casson, Lavona
    Aponte, José
    Vaisberg, Abraham
    Hammond, Gerald
    Bates, Paula
    Affiliation
    Univ Arizona, Coll Med, Div Pulm Allergy Crit Care & Sleep Med
    Issue Date
    2018-06
    Keywords
    plagiochiline A
    Plagiochila disticha
    cytokinesis
    abscission
    
    Metadata
    Show full item record
    Publisher
    MDPI
    Citation
    Stivers, N.S.; Islam, A.; Reyes-Reyes, E.M.; Casson, L.K.; Aponte, J.C.; Vaisberg, A.J.; Hammond, G.B.; Bates, P.J. Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death. Molecules 2018, 23, 1418.
    Journal
    MOLECULES
    Rights
    © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    We previously reported on the isolation and biological activities of plagiochiline A (1), a 2,3-secoaromadendrane-type sesquiterpenoid from the Peruvian medicinal plant, Plagiochila disticha. This compound was found to have antiproliferative effects on a variety of solid tumor cell lines, as well as several leukemia cell lines. Other researchers have also noted the cytotoxicity of plagiochiline A (isolated from different plant species), but there are no prior reports regarding the mechanism for this bioactivity. Here, we have evaluated the effects of plagiochiline A on cell cycle progression in DU145 prostate cancer cells. A cell cycle analysis indicated that plagiochiline A caused a significant increase in the percentage of cells in the G(2)/M phase when compared with control cells. When cells were stained and observed by fluorescence microscopy to examine progress through the mitotic phase, we found a significant increase in the proportion of cells with features of late cytokinesis (cells connected by intercellular bridges) in the plagiochiline A-treated samples. These results suggest that plagiochiline A inhibits cell division by preventing completion of cytokinesis, particularly at the final abscission stage. We also determined that plagiochiline A reduces DU145 cell survival in clonogenic assays and that it induces substantial cell death in these cells.
    Note
    Open access journal.
    ISSN
    1420-3049
    PubMed ID
    29895732
    DOI
    10.3390/molecules23061418
    Version
    Final published version
    Sponsors
    U.S. Department of Defense Prostate Cancer Research Program (PCRP) of the Office of the Congressionally Directed Medical Research Medical Research Program (CDMRP) [W81XWH-07-1-0299]
    Additional Links
    http://www.mdpi.com/1420-3049/23/6/1418
    ae974a485f413a2113503eed53cd6c53
    10.3390/molecules23061418
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Stereostructure of plagiochiline A and conversion of plagiochiline A and stearoylvelutinal into hot-tasting compounds by human saliva.
    • Authors: Hashimoto T, Tanaka H, Asakawa Y
    • Issue date: 1994 Jul
    • Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae).
    • Authors: Aponte JC, Yang H, Vaisberg AJ, Castillo D, Málaga E, Verástegui M, Casson LK, Stivers N, Bates PJ, Rojas R, Fernandez I, Lewis WH, Sarasara C, Sauvain M, Gilman RH, Hammond GB
    • Issue date: 2010 May
    • Cytotoxic 2,3-secoaromadendrane-type sesquiterpenoids from the liverwort Plagiochila ovalifolia.
    • Authors: Toyota M, Tanimura K, Asakawa Y
    • Issue date: 1998 Jun
    • Myriaporones 1-4, cytotoxic metabolites from the Mediterranean bryozoan Myriapora truncata.
    • Authors: Cheng JF, Lee JS, Sakai R, Jares-Erijman EA, Silva MV, Rinehart KL
    • Issue date: 2007 Mar
    • The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.
    • Authors: Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M
    • Issue date: 2010 Jul
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.