Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death
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Stivers, NicoleIslam, Ashraful
Reyes-Reyes, Elsa
Casson, Lavona
Aponte, José
Vaisberg, Abraham
Hammond, Gerald
Bates, Paula
Affiliation
Univ Arizona, Coll Med, Div Pulm Allergy Crit Care & Sleep MedIssue Date
2018-06
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Stivers, N.S.; Islam, A.; Reyes-Reyes, E.M.; Casson, L.K.; Aponte, J.C.; Vaisberg, A.J.; Hammond, G.B.; Bates, P.J. Plagiochiline A Inhibits Cytokinetic Abscission and Induces Cell Death. Molecules 2018, 23, 1418.Journal
MOLECULESRights
© 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
We previously reported on the isolation and biological activities of plagiochiline A (1), a 2,3-secoaromadendrane-type sesquiterpenoid from the Peruvian medicinal plant, Plagiochila disticha. This compound was found to have antiproliferative effects on a variety of solid tumor cell lines, as well as several leukemia cell lines. Other researchers have also noted the cytotoxicity of plagiochiline A (isolated from different plant species), but there are no prior reports regarding the mechanism for this bioactivity. Here, we have evaluated the effects of plagiochiline A on cell cycle progression in DU145 prostate cancer cells. A cell cycle analysis indicated that plagiochiline A caused a significant increase in the percentage of cells in the G(2)/M phase when compared with control cells. When cells were stained and observed by fluorescence microscopy to examine progress through the mitotic phase, we found a significant increase in the proportion of cells with features of late cytokinesis (cells connected by intercellular bridges) in the plagiochiline A-treated samples. These results suggest that plagiochiline A inhibits cell division by preventing completion of cytokinesis, particularly at the final abscission stage. We also determined that plagiochiline A reduces DU145 cell survival in clonogenic assays and that it induces substantial cell death in these cells.Note
Open access journal.ISSN
1420-3049PubMed ID
29895732Version
Final published versionSponsors
U.S. Department of Defense Prostate Cancer Research Program (PCRP) of the Office of the Congressionally Directed Medical Research Medical Research Program (CDMRP) [W81XWH-07-1-0299]Additional Links
http://www.mdpi.com/1420-3049/23/6/1418ae974a485f413a2113503eed53cd6c53
10.3390/molecules23061418
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