Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma
AuthorJacobs, Elizabeth T.
Baron, John A.
Cross, Amanda J.
Lieberman, David A.
Martínez, María Elena
AffiliationUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationJacobs, E. T., Gupta, S., Baron, J. A., Cross, A. J., Lieberman, D. A., Murphy, G., & Martínez, M. E. (2018). Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma. The American Journal of Gastroenterologyvolume 113, 899–905. https://doi.org/10.1038/s41395-018-0007-x
RightsCopyright © 2018, Springer Nature
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractOBJECTIVES: Little is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy. METHODS: We pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma. RESULTS: Compared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95% CI = 1.01-1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95% CI = 1.05-1.53) or sibling (OR = 1.34; 95% CI = 1.11-1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95% CIs) of 1.07 (0.93-1.23) for one relative and 1.39 (1.02-1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95% CIs) of 1.66 (1.08-2.56) for diagnosis at <54 years; 1.34 (0.89-2.03) for 55-64 years; and 1.10 (0.70-1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA. CONCLUSIONS: A family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.
Note6 month embargo; published online: 20 February 2018
VersionFinal accepted manuscript
SponsorsPublic Health Service from the National Cancer Institute [P30CA023074, CA41108, CA23074, CA95060, CA37287, CA104869, CA23108, CA59005, CA26852]; Cooperative Studies Program, Department of Veterans Affairs; Merit Review Award from the United States Department of Veterans Affairs Health Services Research & Development Service of the VA Office of Research and Development [1 I01 HX001574-01A1]; Instituto de Salud Carlos III; Fondos FEDER [PI11/2630, INT-13-078, INT-14-196, UGP-13-221, PI14/01386]; Intramural Research Program of the National Cancer Institute
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