• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Master's Theses
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • UA Theses and Dissertations
    • Master's Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Basal Cell Carcinoma and Its Treatment: Where Do We Go From Here?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    azu_etd_16634_sip1_m.pdf
    Size:
    7.648Mb
    Format:
    PDF
    Download
    Author
    Zullo, Shannon Watson
    Issue Date
    2018
    Keywords
    advanced basal cell carcinoma
    Basal Cell Carcinoma
    hedgehog pathway
    photodynamic therapy
    vismodegib
    Advisor
    Maggert, Keith A.
    Elliott, David A.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Basal cell carcinoma (BCC) is the most common cancer in the United States affecting millions of people annually. The pathophysiology of BCC is multifactorial and is influenced by environmental factors such as ultraviolet radiation exposure and genetics. There are common and aggressive subtypes of BCC, which are further characterized by their clinical appearance and histologic features. The common subtypes, such as nodular and superficial BCC are slow-growing and indolent. In contrast, the aggressive subtypes, such as the morpheaform and sclerotic variants are more likely to result in local tissue destruction, but rarely metastasize. The molecular pathogenesis of BCC was first discovered while studying basal cell nevus syndrome (BCNS), an inherited syndrome, which often manifests with large numbers of BCCs at a young age. BCNS researchers discovered the defective tumor suppressor gene, Patched 1, in the hedgehog signaling pathway that was found to underlie the pathophysiology of the syndrome as well as most sporadic BCCs. From further studies, additional members of the pathway have also been implicated as playing an oncogenic role in the formation of BCC. The gold standard treatment for non-advanced BCC is surgical excision. However, the focus of this review is the treatment of advanced BCCs, such as metastatic and locally advanced forms. Until recently, chemotherapy and radiation were the primary treatments for non-surgically resectable advanced BCCs. Now, with the recent advent of hedgehog pathway inhibitors, innovative treatment modalities for advanced BCC are at the forefront of current research. This thesis aims to conduct a thorough review of the epidemiology, clinical presentation, molecular pathophysiology, and current treatments of basal cell carcinoma with an emphasis on the role and limitations of hedgehog pathway inhibitors. Furthermore, the proposal of this thesis will reflect on the literature to hypothesize the future of advanced basal cell carcinoma treatment.
    Type
    text
    Electronic Thesis
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Cellular and Molecular Medicine
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.