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dc.contributor.advisorWilson, Jean
dc.contributor.authorGottman, Moriah*
dc.creatorGottman, Moriah
dc.date.accessioned2018-10-12T00:20:03Z
dc.date.available2018-10-12T00:20:03Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/630154
dc.description.abstractPostnatal microcephaly in MASA/CRASH (mental retardation, aphasia, shuffling gate, adducted thumbs) syndrome is caused by compromised neurite outgrowth, arborization, and directionality. Neurite outgrowth is lost due to a lack of L1-cellular adhesion molecule (L1CAM, or L1) and ankyrins B and G interaction. Neurite arborization is compromised due to a loss of L1CAM and ezrin-radixin-moesin (ERM) protein interaction. L1CAM and neuropilin-1(NP1) interaction leads to a loss of neurite directionality. How these neurite growth changes affect neurogenesis throughout the brain, and lead to microcephaly (MiC), has not yet been modeled. Future drug discovery projects aiming to halt the progression of postnatal MiC in MASA syndrome could narrow the scope of focus if modeling software parameters were adjusted to reflect phenotypic changes to neurites lacking L1 demonstrated in the literature.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.subjectbranching
dc.subjectL1
dc.subjectMASA
dc.subjectmicrocephaly
dc.subjectmodel
dc.subjectneurites
dc.titlePostnatal Microcephaly in MASA/CRASH Syndrome: L1 Cellular Adhesion Molecule Loss Leads to Smaller, Fewer, and Directionally Challenged Neurites
dc.typetext
dc.typeElectronic Thesis
thesis.degree.grantorUniversity of Arizona
thesis.degree.levelmasters
dc.contributor.committeememberSt. John, Paul
dc.contributor.committeememberMouneimne, Ghassan
dc.description.releaseRelease after 07/09/2023
thesis.degree.disciplineGraduate College
thesis.degree.disciplineCellular and Molecular Medicine
thesis.degree.nameM.S.


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