HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?
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ROYAL SOC CHEMISTRYCitation
Chem. Commun., 2018, 54, 9442Journal
CHEMICAL COMMUNICATIONSRights
© The Royal Society of Chemistry 2018.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.Note
12 month embargo; published online: 31 July 2018ISSN
1359-73451364-548X