HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?
| dc.contributor.author | Amato, Jussara | |
| dc.contributor.author | Madanayake, Thushara W. | |
| dc.contributor.author | Iaccarino, Nunzia | |
| dc.contributor.author | Novellino, Ettore | |
| dc.contributor.author | Randazzo, Antonio | |
| dc.contributor.author | Hurley, Laurence H. | |
| dc.contributor.author | Pagano, Bruno | |
| dc.date.accessioned | 2018-10-12T19:28:45Z | |
| dc.date.available | 2018-10-12T19:28:45Z | |
| dc.date.issued | 2018-09-04 | |
| dc.identifier.citation | Chem. Commun., 2018, 54, 9442 | en_US |
| dc.identifier.issn | 1359-7345 | |
| dc.identifier.issn | 1364-548X | |
| dc.identifier.pmid | 30079419 | |
| dc.identifier.doi | 10.1039/C8CC03614D | |
| dc.identifier.uri | http://hdl.handle.net/10150/630255 | |
| dc.description.abstract | This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex. | en_US |
| dc.description.sponsorship | NCI NIH HHS [R01 CA153821] | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | ROYAL SOC CHEMISTRY | en_US |
| dc.relation.url | http://xlink.rsc.org/?DOI=C8CC03614D | en_US |
| dc.rights | © The Royal Society of Chemistry 2018. | en_US |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.title | HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation? | en_US |
| dc.type | Article | en_US |
| dc.contributor.department | Univ Arizona, Coll Pharm | en_US |
| dc.identifier.journal | CHEMICAL COMMUNICATIONS | en_US |
| dc.description.note | 12 month embargo; published online: 31 July 2018 | en_US |
| dc.description.collectioninformation | This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. | en_US |
| dc.eprint.version | Final accepted manuscript | en_US |
| dc.source.journaltitle | Chemical Communications | |
| dc.source.volume | 54 | |
| dc.source.issue | 68 | |
| dc.source.beginpage | 9442 | |
| dc.source.endpage | 9445 |
Files in this item
Name:
Pagano_Communication_R1_unmark ...
Size:
717.9Kb
Format:
PDF
Description:
Final Accepted Manuscript