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dc.contributor.advisorOgden, Kim
dc.contributor.authorSlosky, Sara Elizabeth
dc.creatorSlosky, Sara Elizabeth
dc.date.accessioned2018-10-17T02:39:05Z
dc.date.available2018-10-17T02:39:05Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/630338
dc.description.abstractThe goal of the proposed plant is to produce 8760 g of bevacizumab at a concentration of 25 mg/mL which yields 349 L of product per year. Bevacizumab is a monoclonal antibody that is used to treat six different types of cancer. It acts by binding to the growth factor which essentially starves the cancerous tumor. To mass produce the antibody, recombinant Chinese Hamster Ovary cells that produce the desired humanized antibody are grown in a cascade of bioreactors. The cell solution then goes through a series of purification steps to isolate the desired antibody. A centrifuge is used to remove cell mass and chromatography columns are used to rid the solution of the undesired proteins. Filtration removes the buffer salts and then the final product is freeze dried. While the startup cost of the proposed plant is high, the pharmaceutical market is very lucrative and the facility is expected to make a profit within the first year. After seven years the investment has an estimated net present value of over $120 million. Due to the high economic return, the proposed plant design should move on to further development and implementation.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.titleMONOCLONAL ANTIBODY PRODUCTION FOR CANCER IMMUNOTHERAPY
dc.typetext
dc.typeElectronic Thesis
thesis.degree.levelbachelors
thesis.degree.disciplineHonors College
thesis.degree.disciplineChemical and Environmental Engineering
thesis.degree.nameB.S.
refterms.dateFOA2018-10-17T02:39:05Z


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