MODELING THE EFFECTS OF ARSENIC INHALATION EXPOSURE ON APICAL BRONCHIAL EPITHELIAL BARRIER FUNCTION
PublisherThe University of Arizona.
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AbstractThis thesis is a research-based approach to determining an experimental model that accurately mimics inhalation of environmentally relevant concentrations of arsenic. The model will be established by using an immortalized human bronchial cell line seeded on filters that allow access to the apical and basolateral surfaces of the upper respiratory epithelium. Further, this model will be used to understand how inhalatory arsenic exposure affects the upper airway epithelial barrier function via tight junction proteins and subsequently contributes to respiratory disease.
Degree ProgramHonors College