MODELING THE EFFECTS OF ARSENIC INHALATION EXPOSURE ON APICAL BRONCHIAL EPITHELIAL BARRIER FUNCTION
Publisher
The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
This thesis is a research-based approach to determining an experimental model that accurately mimics inhalation of environmentally relevant concentrations of arsenic. The model will be established by using an immortalized human bronchial cell line seeded on filters that allow access to the apical and basolateral surfaces of the upper respiratory epithelium. Further, this model will be used to understand how inhalatory arsenic exposure affects the upper airway epithelial barrier function via tight junction proteins and subsequently contributes to respiratory disease.Type
textElectronic Thesis
Degree Name
B.S.H.S.Degree Level
bachelorsDegree Program
Honors CollegePhysiology