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    The Promoting Activity in Cancer Survivors (PACES) trial: a multiphase optimization of strategy approach to increasing physical activity in breast cancer survivors

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    Author
    Rethorst, Chad D.
    Hamann, Heidi A.
    Carmody, Thomas J.
    Sharp, Kendall J.
    Argenbright, Keith E.
    Haley, Barbara B.
    Skinner, Celette Sugg
    Trivedi, Madhukar H.
    Affiliation
    Univ Arizona
    Issue Date
    2018-07-18
    
    Metadata
    Show full item record
    Publisher
    BMC
    Citation
    Rethorst et al. BMC Cancer (2018) 18:744; https://doi.org/10.1186/s12885-018-4662-5
    Journal
    BMC CANCER
    Rights
    © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background: Despite the significant, empirically supported benefits of physical activity, the majority of breast cancer survivors do not meet recommended guidelines for physical activity. A variety of effective strategies to increase physical activity in breast cancer survivors have been identified. However, it is unknown which of these strategies is most effective or how these strategies might be combined to optimize intervention effectiveness. Methods: The proposed trial uses multiphase optimization strategy (MOST) to evaluate four evidence-based intervention strategies for increasing physical activity in breast cancer survivors. We will enroll 500 breast cancer survivors, age 18 and older, who are 3-months to 5 years post-treatment. Using a full-factorial design, participants will be randomized to receive a combination: 1) supervised exercise, 2) facility access, 3) self-monitoring, and 4) group-based active living counseling. The primary outcome, moderate-to-vigorous physical activity (MVPA) will be measured at baseline, 3 months, and 6 months using an Actigraph GT3X+. To evaluate intervention effects, a linear mixed-effects model will be conducted with MVPA as the outcome and with time (3 months and 6 months) as the within-subjects factor and intervention (i.e., supervised exercise, facility access, self-monitoring, and active living counseling) as the between subjects factor, along with all two-way interactions. Discussion: The purpose of the PACES study is to evaluate multiple strategies for increasing physical activity in breast cancer survivors. Results of this study will provide in an optimized intervention for increasing physical activity in breast cancer survivors.
    Note
    Open access journal
    ISSN
    1471-2407
    PubMed ID
    30021554
    DOI
    10.1186/s12885-018-4662-5
    Version
    Final published version
    Sponsors
    Cancer Prevention Research Institute of Texas [PP160121]
    Additional Links
    https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4662-5
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12885-018-4662-5
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