Is increased colorectal screening effective in preventing distant disease?
AffiliationUniv Arizona, Canc Ctr
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationAugustus GJ, Roe DJ, Jacobs ET, Lance P, Ellis NA (2018) Is increased colorectal screening effective in preventing distant disease? PLoS ONE 13(7): e0200462. https://doi.org/10.1371/journal.pone.0200462
Rights© 2018 Augustus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground Screening in the average risk population for colorectal cancer (CRC) is expected to reduce the incidence of distant (i.e., metastatic) CRCs at least as much as less advanced CRCs. Indeed, since 2000, during which time colonoscopy became widely used as a screening tool, the overall incidence of CRC has been reduced by 29%. Objective The purpose of the current study was to determine whether the reduction of incidence rates is the same for all stages of disease. Methods We evaluated incidence data from the Surveillance, Epidemiology, and End Results (SEER) program from 2000-2014 for Localized, Regional, and Distant disease. Joinpoint models were compared to assess parallelism of trends. Data were stratified by race, age, tumor location, and sex to determine whether these subgroupings could explain overall trends. Results Inconsistent with the expectations of a successful screening program, the reduction in incidence rates of distant CRCs from 2000-2014 has been slower than the reductions in incidence rates of both regional and localized CRCs. This trend is evident even when the data are stratified by age at diagnosis, sex, race, or tumor location. Conclusions The slower decrease in the incidence rate of distant disease is not consistent with a screening effect, that is, CRC screening may not be effective in preventing many distant CRCs. As a consequence, distant CRCs represent an increasing fraction of all CRCs, accounting for 21% of all CRCs in 2014. The analysis indicates that inadequate screening does not explain the slower decrease in incidence of distant CRCs. Consequently, we suggest that a subtype of CRC exists that advances rapidly, evading detection because screening intervals are too 161 long to prevent it. Microsatellite unstable tumors represent a known subtype that advances more rapidly, and we suggest that another rapidly advancing subtype very likely exists that is microsatellite stable.
NoteOpen access journal.
VersionFinal published version
SponsorsNational Cancer Institute [U01 CA153060, P30 CA023074]; Cancer Biology Training Grant [T32 CA009213]
- Decrease in Incidence of Colorectal Cancer Among Individuals 50 Years or Older After Recommendations for Population-based Screening.
- Authors: Murphy CC, Sandler RS, Sanoff HK, Yang YC, Lund JL, Baron JA
- Issue date: 2017 Jun
- Interval Colorectal Cancer Incidence Among Subjects Undergoing Multiple Rounds of Fecal Immunochemical Testing.
- Authors: van der Vlugt M, Grobbee EJ, Bossuyt PMM, Bos A, Bongers E, Spijker W, Kuipers EJ, Lansdorp-Vogelaar I, Spaander MCW, Dekker E
- Issue date: 2017 Aug
- Changes in colorectal cancer incidence rates in young and older adults in the United States: what does it tell us about screening.
- Authors: Austin H, Henley SJ, King J, Richardson LC, Eheman C
- Issue date: 2014 Feb
- Screening for Colorectal Cancer Is Associated With Lower Disease Stage: A Population-Based Study.
- Authors: Kubisch CH, Crispin A, Mansmann U, Göke B, Kolligs FT
- Issue date: 2016 Nov
- Rate of early/missed colorectal cancers after colonoscopy in older patients with or without inflammatory bowel disease in the United States.
- Authors: Wang YR, Cangemi JR, Loftus EV Jr, Picco MF
- Issue date: 2013 Mar