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dc.contributor.authorKeerthivasan, Mahesh Bharath
dc.contributor.authorMandava, Sagar
dc.contributor.authorJohnson, Kevin
dc.contributor.authorAvery, Ryan
dc.contributor.authorJanardhanan, Rajesh
dc.contributor.authorMartin, Diego R.
dc.contributor.authorBilgin, Ali
dc.contributor.authorAltbach, Maria I.
dc.date.accessioned2018-11-26T23:48:05Z
dc.date.available2018-11-26T23:48:05Z
dc.date.issued2018-07-19
dc.identifier.citationKeerthivasan et al. Journal of Cardiovascular Magnetic Resonance (2018) 20:49en_US
dc.identifier.issn1532-429X
dc.identifier.pmid30025523
dc.identifier.doi10.1186/s12968-018-0470-y
dc.identifier.urihttp://hdl.handle.net/10150/631066
dc.description.abstractBackground: Double inversion recovery (DIR) fast spin-echo (FSE) cardiovascular magnetic resonance (CMR) sequences are used clinically for black-blood T2-weighted imaging. However, these sequences suffer from slice inefficiency due to the non-selective inversion pulses. We propose a multi-band (MB) encoded DIR radial FSE (MB-DIR-RADFSE) technique to simultaneously excite two slices. This sequence has improved signal-to-noise ratio per unit time compared to a single slice excitation. It is also motion robust and enables the reconstruction of high-resolution black-blood T2-weighted images and T2 maps for the excited slices. Methods: Hadamard encoded MB pulses were used in MB-DIR-RADFSE to simultaneously excite two slices. A principal component based iterative reconstruction was used to jointly reconstruct black-blood T2-weighted images and T2 maps. Phantom and in vivo experiments were performed to evaluate T2 mapping performance and results were compared to a T2-prepared balanced steady state free precession (bSSFP) method. The inter-segment variability of the T2 maps were assessed using data acquired on healthy subjects. A reproducibility study was performed to evaluate reproducibility of the proposed technique. Results: Phantom experiments show that the T2 values estimated from MB-DIR-RADFSE are comparable to the spin-echo based reference, while T2-prepared bSSFP over-estimated T2 values. The relative contrast of the black-blood images from the multi-band scheme was comparable to those from a single slice acquisition. The myocardial segment analysis on 8 healthy subjects indicated a significant difference (p-value < 0.01) in the T2 estimates from the apical slice when compared to the mid-ventricular slice. The mean T2 estimate from 12 subjects obtained using T2-prepared bSSFP was significantly higher (p-value = 0.012) compared to MB-DIR-RADFSE, consistent with the phantom results. The Bland-Altman analysis showed excellent reproducibility between the MB-DIR-RADFSE measurements, with a mean T2 difference of 0.12 ms and coefficient of reproducibility of 2.07 in 15 clinical subjects. The utility of this technique is demonstrated in two subjects where the T2 maps show elevated values in regions of pathology. Conclusions: The use of multi-band pulses for excitation improves the slice efficiency of the double inversion fast spin-echo pulse sequence. The use of a radial trajectory and a joint reconstruction framework allows reconstruction of TE images and T2 maps for the excited slices.en_US
dc.description.sponsorshipNIH [R01HL085385]en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.urlhttps://jcmr-online.biomedcentral.com/articles/10.1186/s12968-018-0470-yen_US
dc.rights© The Author(s). 2018en_US
dc.subjectMulti-band pulsesen_US
dc.subjectRadialen_US
dc.subjectFast spin echoen_US
dc.subjectBlack blood imagingen_US
dc.subjectDouble inversion recoveryen_US
dc.subjectT2 mappingen_US
dc.titleA multi-band double-inversion radial fast spin-echo technique for T2 cardiovascular magnetic resonance mapping of the hearten_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Elect & Comp Engnen_US
dc.contributor.departmentUniv Arizona, Dept Med Imagingen_US
dc.contributor.departmentUniv Arizona, Dept Meden_US
dc.contributor.departmentUniv Arizona, Dept Biomed Engnen_US
dc.identifier.journalJOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCEen_US
dc.description.noteOpen access journal.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleJournal of Cardiovascular Magnetic Resonance
dc.source.volume20
dc.source.issue1
refterms.dateFOA2018-11-26T23:48:05Z


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