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    The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion

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    s41467-018-05367-2.pdf
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    Author
    Padilla-Rodriguez, Marco
    Parker, Sara S.
    Adams, Deanna G.
    Westerling, Thomas
    Puleo, Julieann I.
    Watson, Adam W.
    Hill, Samantha M.
    Noon, Muhammad
    Gaudin, Raphael
    Aaron, Jesse
    Tong, Daoqin
    Roe, Denise J.
    Knudsen, Beatrice
    Mouneimne, Ghassan
    Show allShow less
    Affiliation
    Univ Arizona, BioComp Facil
    Univ Arizona, Coll Social & Behav Sci, Sch Geog & Dev
    Univ Arizona, Ctr Canc
    Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth
    Issue Date
    2018-07-30
    
    Metadata
    Show full item record
    Publisher
    NATURE PUBLISHING GROUP
    Citation
    Padilla-Rodriguez, M., Parker, S. S., Adams, D. G., Westerling, T., Puleo, J. I., Watson, A. W., ... Mouneimne, G. (2018). The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nature Communications, 9(1), [2980]. https://doi.org/10.1038/s41467-018-05367-2
    Journal
    NATURE COMMUNICATIONS
    Rights
    © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Estrogen promotes growth of estrogen receptor-positive (ER+) breast tumors. However, epidemiological studies examining the prognostic characteristics of breast cancer in postmenopausal women receiving hormone replacement therapy reveal a significant decrease in tumor dissemination, suggesting that estrogen has potential protective effects against cancer cell invasion. Here, we show that estrogen suppresses invasion of ER+ breast cancer cells by increasing transcription of the Ena/VASP protein, EVL, which promotes the generation of suppressive cortical actin bundles that inhibit motility dynamics, and is crucial for the ERmediated suppression of invasion in vitro and in vivo. Interestingly, despite its benefits in suppressing tumor growth, anti-estrogenic endocrine therapy decreases EVL expression and increases local invasion in patients. Our results highlight the dichotomous effects of estrogen on tumor progression and suggest that, in contrast to its established role in promoting growth of ER+ tumors, estrogen has a significant role in suppressing invasion through actin cytoskeletal remodeling.
    ISSN
    2041-1723
    PubMed ID
    30061623
    DOI
    10.1038/s41467-018-05367-2
    Version
    Final published version
    Sponsors
    Gordon and Betty Moore Foundation; Howard Hughes Medical Institute; NCI grant [RO1 CA196885-01]; Science Foundation Arizona Bisgrove Scholars Postdoctoral Fellowship; NCI University of Arizona Cancer Center Support Grant [P30CA023074]
    Additional Links
    http://www.nature.com/articles/s41467-018-05367-2
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-018-05367-2
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