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dc.contributor.authorPadilla-Rodriguez, Marco
dc.contributor.authorParker, Sara S.
dc.contributor.authorAdams, Deanna G.
dc.contributor.authorWesterling, Thomas
dc.contributor.authorPuleo, Julieann I.
dc.contributor.authorWatson, Adam W.
dc.contributor.authorHill, Samantha M.
dc.contributor.authorNoon, Muhammad
dc.contributor.authorGaudin, Raphael
dc.contributor.authorAaron, Jesse
dc.contributor.authorTong, Daoqin
dc.contributor.authorRoe, Denise J.
dc.contributor.authorKnudsen, Beatrice
dc.contributor.authorMouneimne, Ghassan
dc.date.accessioned2018-12-05T21:00:37Z
dc.date.available2018-12-05T21:00:37Z
dc.date.issued2018-07-30
dc.identifier.citationPadilla-Rodriguez, M., Parker, S. S., Adams, D. G., Westerling, T., Puleo, J. I., Watson, A. W., ... Mouneimne, G. (2018). The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nature Communications, 9(1), [2980]. https://doi.org/10.1038/s41467-018-05367-2en_US
dc.identifier.issn2041-1723
dc.identifier.pmid30061623
dc.identifier.doi10.1038/s41467-018-05367-2
dc.identifier.urihttp://hdl.handle.net/10150/631111
dc.description.abstractEstrogen promotes growth of estrogen receptor-positive (ER+) breast tumors. However, epidemiological studies examining the prognostic characteristics of breast cancer in postmenopausal women receiving hormone replacement therapy reveal a significant decrease in tumor dissemination, suggesting that estrogen has potential protective effects against cancer cell invasion. Here, we show that estrogen suppresses invasion of ER+ breast cancer cells by increasing transcription of the Ena/VASP protein, EVL, which promotes the generation of suppressive cortical actin bundles that inhibit motility dynamics, and is crucial for the ERmediated suppression of invasion in vitro and in vivo. Interestingly, despite its benefits in suppressing tumor growth, anti-estrogenic endocrine therapy decreases EVL expression and increases local invasion in patients. Our results highlight the dichotomous effects of estrogen on tumor progression and suggest that, in contrast to its established role in promoting growth of ER+ tumors, estrogen has a significant role in suppressing invasion through actin cytoskeletal remodeling.en_US
dc.description.sponsorshipGordon and Betty Moore Foundation; Howard Hughes Medical Institute; NCI grant [RO1 CA196885-01]; Science Foundation Arizona Bisgrove Scholars Postdoctoral Fellowship; NCI University of Arizona Cancer Center Support Grant [P30CA023074]en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.urlhttp://www.nature.com/articles/s41467-018-05367-2en_US
dc.rights© The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.titleThe actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasionen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, BioComp Facilen_US
dc.contributor.departmentUniv Arizona, Coll Social & Behav Sci, Sch Geog & Deven_US
dc.contributor.departmentUniv Arizona, Ctr Cancen_US
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlthen_US
dc.identifier.journalNATURE COMMUNICATIONSen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleNature Communications
dc.source.volume9
dc.source.issue1
refterms.dateFOA2018-12-05T21:00:38Z


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