Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study
AffiliationUniv Arizona, Dept Med, Coll Med Phoenix
MetadataShow full item record
CitationSyed S. Zaidi, Ryan D. Ward, Kodangudi Ramanathan, Xinhua Yu, Inna P. Gladysheva, and Guy L. Reed, “Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study,” BioMed Research International, vol. 2018, Article ID 7279036, 6 pages, 2018. https://doi.org/10.1155/2018/7279036.
JournalBIOMED RESEARCH INTERNATIONAL
Rights© 2018 Syed S. Zaidi et al. This is an open access article distributed under the Creative Commons Attribution License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBackground. In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood. Methods and Results. This pilot study (n=48) compared plasma levels of corin, neprilysin, ANP, BNP, and cGMP in control patients with normal ejection fractions (mean EF 63 +/- 3%) versus patients with systolic dysfunction, with (EF 24 +/- 8%) and without (EF 27 +/- 7%) decompensated HF (dHF), as defined by Framingham and BNP criteria. Mean ages, use of beta blockers, and ACE-inhibitors-angiotensin receptor blockers were similar between the groups. Corin levels were depressed in systolic dysfunction patients (797 +/- 346 pg/ml) versus controls (1188 +/- 549, p<0.02), but levels were not affected by dHF (p=0.77). In contrast, levels of neprilysin (p<0.01), cGMP (p<0.001), and ANP (p<0.001) were higher in systolic dysfunction patients than controls and were the highest in patients with dHF. Conclusions. Levels of neprilysin, ANP, BNP, and cGMP increased in patients with reduced systolic function and were the highest in dHF patients. Conversely, corin levels were low in patients with reduced EF with or without dHF. This pattern suggests possible enzymatic downregulation of natriuretic peptide activity in patients with reduced EF, which may have diagnostic and prognostic implications.
NoteOpen access journal.
VersionFinal published version
SponsorsNational Institutes of Health [HL92750, NS089707, HL115036]