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dc.contributor.authorZaidi, Syed S.
dc.contributor.authorWard, Ryan D.
dc.contributor.authorRamanathan, Kodangudi
dc.contributor.authorYu, Xinhua
dc.contributor.authorGladysheva, Inna P.
dc.contributor.authorReed, Guy L.
dc.date.accessioned2018-12-05T23:09:48Z
dc.date.available2018-12-05T23:09:48Z
dc.date.issued2018
dc.identifier.citationSyed S. Zaidi, Ryan D. Ward, Kodangudi Ramanathan, Xinhua Yu, Inna P. Gladysheva, and Guy L. Reed, “Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study,” BioMed Research International, vol. 2018, Article ID 7279036, 6 pages, 2018. https://doi.org/10.1155/2018/7279036.en_US
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.doi10.1155/2018/7279036
dc.identifier.urihttp://hdl.handle.net/10150/631123
dc.description.abstractBackground. In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood. Methods and Results. This pilot study (n=48) compared plasma levels of corin, neprilysin, ANP, BNP, and cGMP in control patients with normal ejection fractions (mean EF 63 +/- 3%) versus patients with systolic dysfunction, with (EF 24 +/- 8%) and without (EF 27 +/- 7%) decompensated HF (dHF), as defined by Framingham and BNP criteria. Mean ages, use of beta blockers, and ACE-inhibitors-angiotensin receptor blockers were similar between the groups. Corin levels were depressed in systolic dysfunction patients (797 +/- 346 pg/ml) versus controls (1188 +/- 549, p<0.02), but levels were not affected by dHF (p=0.77). In contrast, levels of neprilysin (p<0.01), cGMP (p<0.001), and ANP (p<0.001) were higher in systolic dysfunction patients than controls and were the highest in patients with dHF. Conclusions. Levels of neprilysin, ANP, BNP, and cGMP increased in patients with reduced systolic function and were the highest in dHF patients. Conversely, corin levels were low in patients with reduced EF with or without dHF. This pattern suggests possible enzymatic downregulation of natriuretic peptide activity in patients with reduced EF, which may have diagnostic and prognostic implications.en_US
dc.description.sponsorshipNational Institutes of Health [HL92750, NS089707, HL115036]en_US
dc.language.isoenen_US
dc.publisherHINDAWI LTDen_US
dc.relation.urlhttps://www.hindawi.com/journals/bmri/2018/7279036/en_US
dc.rights© 2018 Syed S. Zaidi et al. This is an open access article distributed under the Creative Commons Attribution License.en_US
dc.titlePossible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Studyen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Med, Coll Med Phoenixen_US
dc.identifier.journalBIOMED RESEARCH INTERNATIONALen_US
dc.description.noteOpen access journal.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleBioMed Research International
dc.source.volume2018
dc.source.beginpage1
dc.source.endpage6
refterms.dateFOA2018-12-05T23:09:49Z


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