Rehabilitation modality and onset differentially influence whisker sensory hypersensitivity after diffuse traumatic brain injury in the rat
AuthorThomas, Theresa Currier
Stockhausen, Ellen Magee
Law, L. Matthew
AffiliationUniversity of Arizona College of Medicine
diffuse traumatic brain injury
whisker barrel circuit
MetadataShow full item record
CitationThomas, T. C., Stockhausen, E. M., Law, L. M., Khodadad, A., & Lifshitz, J. (2017). Rehabilitation modality and onset differentially influence whisker sensory hypersensitivity after diffuse traumatic brain injury in the rat. Restorative neurology and neuroscience, (Preprint), 1-19.
RightsCopyright ©2017 The Authors
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractBACKGROUND: As rehabilitation strategies advance as therapeutic interventions, the modality and onset of rehabilitation after traumatic brain injury (TBI) are critical to optimize treatment. Our laboratory has detected and characterized a late-onset, long-lasting sensory hypersensitivity to whisker stimulation in diffuse brain-injured rats; a deficit that is comparable to visual or auditory sensory hypersensitivity in humans with an acquired brain injury. OBJECTIVE: We hypothesize that the modality and onset of rehabilitation therapies will differentially influence sensory hypersensitivity in response to the Whisker Nuisance Task (WNT) as well as WNT-induced corticosterone (CORT) stress response in diffuse brain-injured rats and shams. METHODS: After midline fluid percussion brain injury (FPI) or sham surgery, rats were assigned to one of four rehabilitative interventions: (1) whisker sensory deprivation during week one or (2) week two or (3) whisker stimulation during week one or (4) week two. At 28 days following FPI and sham procedures, sensory hypersensitivity was assessed using the WNT. Plasma CORT was evaluated immediately following the WNT (aggravated levels) and prior to the pre-determined endpoint 24 hours later (non-aggravated levels). RESULTS: Deprivation therapy during week two elicited significantly greater sensory hypersensitivity to the WNT compared to week one (p < 0.05), and aggravated CORT levels in FPI rats were significantly lower than sham levels. Stimulation therapy during week one resulted in low levels of sensory hypersensitivity to the WNT, similar to deprivation therapy and naïve controls, however, non-aggravated CORT levels in FPI rats were significantly higher than sham. CONCLUSION: These data indicate that modality and onset of sensory rehabilitation can differentially influence FPI and sham rats, having a lasting impact on behavioral and stress responses to the WNT, emphasizing the necessity for continued evaluation of modality and onset of rehabilitation after TBI.
VersionFinal accepted manuscript
- The whisker nuisance task identifies a late-onset, persistent sensory sensitivity in diffuse brain-injured rats.
- Authors: McNamara KC, Lisembee AM, Lifshitz J
- Issue date: 2010 Apr
- Comparison of rat sensory behavioral tasks to detect somatosensory morbidity after diffuse brain-injury.
- Authors: Learoyd AE, Lifshitz J
- Issue date: 2012 Jan 1
- Does time heal all wounds? Experimental diffuse traumatic brain injury results in persisting histopathology in the thalamus.
- Authors: Thomas TC, Ogle SB, Rumney BM, May HG, Adelson PD, Lifshitz J
- Issue date: 2018 Mar 15
- Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
- Authors: Cao T, Thomas TC, Ziebell JM, Pauly JR, Lifshitz J
- Issue date: 2012 Dec 6
- Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses.
- Authors: Hall KD, Lifshitz J
- Issue date: 2010 Apr 6