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    Rehabilitation modality and onset differentially influence whisker sensory hypersensitivity after diffuse traumatic brain injury in the rat

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    Thomas_Time_and_Modality_RNN_r ...
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    Author
    Thomas, Theresa Currier
    Stockhausen, Ellen Magee
    Law, L. Matthew
    Khodadad, Aida
    Lifshitz, Jonathan
    Affiliation
    University of Arizona College of Medicine
    Issue Date
    2017-11
    Keywords
    Rehabilitation
    diffuse traumatic brain injury
    physical therapy
    sensory sensitivity
    whisker barrel circuit
    
    Metadata
    Show full item record
    Publisher
    IOS PRESS
    Citation
    Thomas, T. C., Stockhausen, E. M., Law, L. M., Khodadad, A., & Lifshitz, J. (2017). Rehabilitation modality and onset differentially influence whisker sensory hypersensitivity after diffuse traumatic brain injury in the rat. Restorative neurology and neuroscience, (Preprint), 1-19.
    Journal
    RESTORATIVE NEUROLOGY AND NEUROSCIENCE
    Rights
    Copyright © 2017 The Authors.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    BACKGROUND: As rehabilitation strategies advance as therapeutic interventions, the modality and onset of rehabilitation after traumatic brain injury (TBI) are critical to optimize treatment. Our laboratory has detected and characterized a late-onset, long-lasting sensory hypersensitivity to whisker stimulation in diffuse brain-injured rats; a deficit that is comparable to visual or auditory sensory hypersensitivity in humans with an acquired brain injury. OBJECTIVE: We hypothesize that the modality and onset of rehabilitation therapies will differentially influence sensory hypersensitivity in response to the Whisker Nuisance Task (WNT) as well as WNT-induced corticosterone (CORT) stress response in diffuse brain-injured rats and shams. METHODS: After midline fluid percussion brain injury (FPI) or sham surgery, rats were assigned to one of four rehabilitative interventions: (1) whisker sensory deprivation during week one or (2) week two or (3) whisker stimulation during week one or (4) week two. At 28 days following FPI and sham procedures, sensory hypersensitivity was assessed using the WNT. Plasma CORT was evaluated immediately following the WNT (aggravated levels) and prior to the pre-determined endpoint 24 hours later (non-aggravated levels). RESULTS: Deprivation therapy during week two elicited significantly greater sensory hypersensitivity to the WNT compared to week one (p < 0.05), and aggravated CORT levels in FPI rats were significantly lower than sham levels. Stimulation therapy during week one resulted in low levels of sensory hypersensitivity to the WNT, similar to deprivation therapy and naïve controls, however, non-aggravated CORT levels in FPI rats were significantly higher than sham. CONCLUSION: These data indicate that modality and onset of sensory rehabilitation can differentially influence FPI and sham rats, having a lasting impact on behavioral and stress responses to the WNT, emphasizing the necessity for continued evaluation of modality and onset of rehabilitation after TBI.
    ISSN
    09226028
    18783627
    PubMed ID
    29036852
    DOI
    10.3233/RNN-170753
    Version
    Final accepted manuscript
    Additional Links
    http://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/RNN-170753
    ae974a485f413a2113503eed53cd6c53
    10.3233/RNN-170753
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