• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    fimmu-09-01882.pdf
    Size:
    7.581Mb
    Format:
    PDF
    Description:
    Final Published version
    Download
    Author
    Pierucci-Alves, Fernando
    Midura-Kiela, Monica T.
    Fleming, Sherry D.
    Schultz, Bruce D.
    Kiela, Pawel R.
    Affiliation
    Univ Arizona, Dept Pediat
    Univ Arizona, Dept Immunobiol
    Issue Date
    2018-09-16
    Keywords
    sperm tolerance
    infertility
    autoimmunity
    transforming growth factor
    dendritic cells
    
    Metadata
    Show full item record
    Publisher
    FRONTIERS MEDIA SA
    Citation
    Pierucci-Alves F, Midura-Kiela MT, Fleming SD, Schultz BD and Kiela PR (2018) Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis. Front. Immunol. 9:1882. doi: 10.3389/fimmu.2018.01882
    Journal
    FRONTIERS IN IMMUNOLOGY
    Rights
    © 2018 Pierucci-Alves, Midura-Kiela, Fleming, Schultz and Kiela. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The epididymis exhibits a less restrictive physical blood-tissue barrier than the testis and, while numerous immunosuppressive factors have been identified in the latter, no mechanisms for epididymal immunotolerance have been identified to date. Therefore, data are currently insufficient to explain how the immune system tolerates the extremely large load of novel antigens expressed on sperm, which become present in the male body after puberty, i.e., long after central tolerance was established. This study tested the hypothesis that transforming growth factor beta (TGF beta) signaling in dendritic cells (DCs) is required for immunotolerance to sperm located in the epididymis, and that male mice lacking TGF beta signaling in DCs would develop severe epididymal inflammation. To test this, we employed adult Tgfbr2(Delta DC) males, which exhibit a significant reduction of Tgfbr2 expression and TGF beta signaling in DCs, as reported previously. Results show that Tgfbr2(Delta DC) males exhibit sperm-specific immune response and severe epididymal leukocytosis. This phenotype is consistent with epididymal loss of immunotolerance to sperm and suggests that TGF beta signaling in DCs is a factor required for a non-inflammatory steady state in the epididymis, and therefore for male tract homeostasis and function.
    Note
    Open access journal.
    ISSN
    1664-3224
    PubMed ID
    30166986
    DOI
    10.3389/fimmu.2018.01882
    Version
    Final published version
    Sponsors
    NIH/NIGMS [P20 GM103418]; K-State Johnson Cancer Research Center; K-State College of Veterinary Medicine; NIH [5R01 DK109711]
    Additional Links
    https://www.frontiersin.org/article/10.3389/fimmu.2018.01882/full
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2018.01882
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

    Related articles

    • Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells.
    • Authors: Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA
    • Issue date: 2009 Sep
    • Junctional adhesion molecule A: expression in the murine epididymal tract and accessory organs and acquisition by maturing sperm.
    • Authors: Wu KZ, Li K, Galileo DS, Martin-DeLeon PA
    • Issue date: 2017 Feb 10
    • Differential expression and localisation of TGF-β isoforms and receptors in the murine epididymis.
    • Authors: Voisin A, Damon-Soubeyrand C, Bravard S, Saez F, Drevet JR, Guiton R
    • Issue date: 2020 Jan 22
    • Macrophages and dendritic cells in the post-testicular environment.
    • Authors: Da Silva N, Barton CR
    • Issue date: 2016 Jan
    • Characterisation of dendritic cell subsets in chronically inflamed human epididymis.
    • Authors: Duan YG, Wang P, Zheng W, Zhang Q, Huang W, Jin F, Cai Z
    • Issue date: 2016 May
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.