The associations between anthropometric measurements and left ventricular structure and function: the Echo-SOL Study

Abstract

Objective The objective of this study is to determine associations between anthropometry and echocardiographic measures of cardiac structure and function in Hispanic/Latinos. Methods A total of 1,824 participants from ECHO-SOL were included. We evaluated associations between echocardiographic measures of left ventricular structure and function and anthropometric measures using multivariable-adjusted linear and logistic regression models adjusting for traditional cardiovascular risk factors. Results The mean age was 560.17years, 57% were women. The mean body mass index (BMI) was 30 +/- 9.4kgm(-2), waist circumference (WC) was 100 +/- 18cm, and waist-to-hip ratio (WHR) was 0.93 +/- 0.15. Adjusted analysis showed that 5-unit increment in BMI and 5-cm increase in WC was associated with 3.4 +/- 0.6 and 1.05 +/- 0.05gm(-2.7) (p<0.05 for both) higher left ventricular (LV) mass index, respectively. Similarly, 0.1-unit increment in WHR was associated with 2.0 +/- 0.16gm(-2.7) higher LV mass index (p<0.01). WHR was associated with 0.22 +/- 0.08% decrease in ejection fraction (p<0.05). Concomitantly, 5-unit increment in BMI and WC was associated with increased odds of abnormal LV geometry (odds ratio 1.40 and 1.16, p=0.03 and <0.01, respectively); 0.1-unit increment in WHR was associated with increased odds of abnormal LV geometry (odds ratio 1.51, p<0.01). Conclusions Among Hispanic/Latinos, higher anthropometric measures were associated with adverse cardiac structure and function.