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    The Cohesive Metastasis Phenotype in Human Prostate Cancer

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    Final accepted manuscript
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    Author
    Harryman, William L (a)
    Hinton, James P (b)
    Rubenstein, Cynthia P (b)
    Singh, Parminder (a)
    Nagle, Raymond B (a)
    Parker, Sarah J (c)
    Knudsen, Beatrice S (c)
    Cress, Anne E (a)
    Affiliation
    The University of Arizona Cancer Center
    Cancer Biology Graduate Program
    Cedars Sinai Medical Center
    Issue Date
    2016-09-24
    Keywords
    adhesome
    Circulating Tumor Cells
    cohesive-clusters
    integrins
    prostate cancer
    metastasis
    
    Metadata
    Show full item record
    Publisher
    ELSEVIER SCIENCE BV
    Citation
    The Cohesive Metastasis Phenotype in Human Prostate Cancer. 2016, 1866 (2):221-231 Biochim. Biophys. Acta
    Journal
    Biochimica et biophysica acta
    Rights
    © 2016 Published by Elsevier B.V.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    A critical barrier for the successful prevention and treatment of recurrent prostate cancer is detection and eradication of metastatic and therapy-resistant disease. Despite the fall in diagnoses and mortality, the reported incidence of metastatic disease has increased 72% since 2004. Prostate cancer arises in cohesive groups as intraepithelial neoplasia, migrates through muscle and leaves the gland via perineural invasion for hematogenous dissemination. Current technological advances have shown cohesive-clusters of tumor (also known as microemboli) within the circulation. Circulating tumor cell (CTC) profiles are indicative of disseminated prostate cancer, and disseminated tumor cells (DTC) are found in cohesive-clusters, a phenotypic characteristic of both radiation- and drug-resistant tumors. Recent reports in cell biology and informatics, coupled with mass spectrometry, indicate that the integrin adhesome network provides an explanation for the biophysical ability of cohesive-clusters of tumor cells to invade thorough muscle and nerve microenvironments while maintaining adhesion-dependent therapeutic resistance. Targeting cohesive-clusters takes advantage of the known ability of extracellular matrix (ECM) adhesion to promote tumor cell survival and represents an approach that has the potential to avoid the progression to drug- and radiotherapy-resistance. In the following review we will examine the evidence for development and dissemination of cohesive-clusters in metastatic prostate cancer.
    Note
    12 month embargo; available online 24 September 2016
    ISSN
    0006-3002
    PubMed ID
    27678419
    DOI
    10.1016/j.bbcan.2016.09.005
    Version
    Final accepted manuscript
    Sponsors
    NIH grants RO1 CA159406 (AEC), RO1 CA131255 (BSK), P50 CA092131 (BSK), K99HL128787 (SJP), T32 CA09213, and P30 CA23074 and P50 CA092131. Other support included DoD-PC131996 (BSK), Prostate Cancer Foundation Creativity Award (BSK), and the Steven Spielberg Team Science Award (BSK).
    Additional Links
    https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=27678419
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bbcan.2016.09.005
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