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    Discovery and genome characterization of three new Jeilongviruses, a lineage of paramyxoviruses characterized by their unique membrane proteins

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    Author
    Vanmechelen, Bert
    Bletsa, Magda
    Laenen, Lies
    Lopes, Ana Rita
    Vergote, Valentijn
    Beller, Leen
    Deboutte, Ward
    Korva, Miša
    Avšič Županc, Tatjana
    Goüy de Bellocq, Joëlle
    Gryseels, Sophie
    Leirs, Herwig
    Lemey, Philippe
    Vrancken, Bram
    Maes, Piet
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    Affiliation
    Univ Arizona, Ecol & Evolutionary Biol Dept
    Issue Date
    2018-08-16
    Keywords
    PMPV-1
    MMLPV-1
    MMLPV-2
    G protein
    Cell attachment protein
    Rodent paramyxovirus
    
    Metadata
    Show full item record
    Publisher
    BMC
    Citation
    Vanmechelen et al. BMC Genomics (2018) 19:617. https://doi.org/10.1186/s12864-018-4995-0
    Journal
    BMC GENOMICS
    Rights
    © The Author(s). 2018
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background: In the past decade, many new paramyxoviruses that do not belong to any of the seven established genera in the family Paramyxoviridae have been discovered. Amongst them are J-virus (JPV), Beilong virus (BeiPV) and Tailam virus (TlmPV), three paramyxovirus species found in rodents. Based on their similarities, it has been suggested that these viruses should compose a new genus, tentatively called 'Jeilongvirus'. Results: Here we present the complete genomes of three newly discovered paramyxoviruses, one found in a bank vole (Myodes glareolus) from Slovenia and two in a single, co-infected Rungwe brush-furred rat (Lophuromys machangui) from Mozambique, that represent three new, separate species within the putative genus 'Jeilongvirus'. The genome organization of these viruses is similar to other paramyxoviruses, but like JPV, BeiPV and TlmPV, they possess an additional open reading frame, encoding a transmembrane protein, that is located between the F and G genes. As is the case for all Jeilongviruses, the G genes of the viruses described here are unusually large, and their encoded proteins are characterized by a remarkable amino acid composition pattern that is not seen in other paramyxoviruses, but resembles certain motifs found in Orthopneumovirus G proteins. Conclusions: The phylogenetic clustering of JPV, BeiPV and TlmPV with the viruses described here, as well as their shared features that set them apart from other paramyxoviruses, provide additional support for the recognition of the genus 'Jeilongvirus'.
    Note
    Open access journal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
    ISSN
    1471-2164
    PubMed ID
    30115009
    DOI
    10.1186/s12864-018-4995-0
    Version
    Final published version
    Sponsors
    Fonds Wetenschappelijk Onderzoek/Research foundation Flanders [1S28617N, 1S61618N, 1167112N, 12T1117N, 12U7118N, G066215N, G0D5117N, G0B9317N]; Slovenian Research Agency [P3-0083]; Czech Science Foundation [P506-10-0983]; European Research Council under the European Union [653316, 725422]
    Additional Links
    https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4995-0
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12864-018-4995-0
    Scopus Count
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