Discovery and genome characterization of three new Jeilongviruses, a lineage of paramyxoviruses characterized by their unique membrane proteins
Author
Vanmechelen, BertBletsa, Magda
Laenen, Lies
Lopes, Ana Rita
Vergote, Valentijn
Beller, Leen
Deboutte, Ward
Korva, Miša
Avšič Županc, Tatjana
Goüy de Bellocq, Joëlle
Gryseels, Sophie
Leirs, Herwig
Lemey, Philippe
Vrancken, Bram
Maes, Piet
Affiliation
Univ Arizona, Ecol & Evolutionary Biol DeptIssue Date
2018-08-16
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BMCCitation
Vanmechelen et al. BMC Genomics (2018) 19:617. https://doi.org/10.1186/s12864-018-4995-0Journal
BMC GENOMICSRights
© The Author(s). 2018Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Background: In the past decade, many new paramyxoviruses that do not belong to any of the seven established genera in the family Paramyxoviridae have been discovered. Amongst them are J-virus (JPV), Beilong virus (BeiPV) and Tailam virus (TlmPV), three paramyxovirus species found in rodents. Based on their similarities, it has been suggested that these viruses should compose a new genus, tentatively called 'Jeilongvirus'. Results: Here we present the complete genomes of three newly discovered paramyxoviruses, one found in a bank vole (Myodes glareolus) from Slovenia and two in a single, co-infected Rungwe brush-furred rat (Lophuromys machangui) from Mozambique, that represent three new, separate species within the putative genus 'Jeilongvirus'. The genome organization of these viruses is similar to other paramyxoviruses, but like JPV, BeiPV and TlmPV, they possess an additional open reading frame, encoding a transmembrane protein, that is located between the F and G genes. As is the case for all Jeilongviruses, the G genes of the viruses described here are unusually large, and their encoded proteins are characterized by a remarkable amino acid composition pattern that is not seen in other paramyxoviruses, but resembles certain motifs found in Orthopneumovirus G proteins. Conclusions: The phylogenetic clustering of JPV, BeiPV and TlmPV with the viruses described here, as well as their shared features that set them apart from other paramyxoviruses, provide additional support for the recognition of the genus 'Jeilongvirus'.Note
Open access journal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.ISSN
1471-2164PubMed ID
30115009Version
Final published versionSponsors
Fonds Wetenschappelijk Onderzoek/Research foundation Flanders [1S28617N, 1S61618N, 1167112N, 12T1117N, 12U7118N, G066215N, G0D5117N, G0B9317N]; Slovenian Research Agency [P3-0083]; Czech Science Foundation [P506-10-0983]; European Research Council under the European Union [653316, 725422]ae974a485f413a2113503eed53cd6c53
10.1186/s12864-018-4995-0
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