Show simple item record

dc.contributor.authorVanmechelen, Bert
dc.contributor.authorBletsa, Magda
dc.contributor.authorLaenen, Lies
dc.contributor.authorLopes, Ana Rita
dc.contributor.authorVergote, Valentijn
dc.contributor.authorBeller, Leen
dc.contributor.authorDeboutte, Ward
dc.contributor.authorKorva, Miša
dc.contributor.authorAvšič Županc, Tatjana
dc.contributor.authorGoüy de Bellocq, Joëlle
dc.contributor.authorGryseels, Sophie
dc.contributor.authorLeirs, Herwig
dc.contributor.authorLemey, Philippe
dc.contributor.authorVrancken, Bram
dc.contributor.authorMaes, Piet
dc.date.accessioned2019-01-02T17:22:19Z
dc.date.available2019-01-02T17:22:19Z
dc.date.issued2018-08-16
dc.identifier.citationVanmechelen et al. BMC Genomics (2018) 19:617. https://doi.org/10.1186/s12864-018-4995-0en_US
dc.identifier.issn1471-2164
dc.identifier.pmid30115009
dc.identifier.doi10.1186/s12864-018-4995-0
dc.identifier.urihttp://hdl.handle.net/10150/631246
dc.description.abstractBackground: In the past decade, many new paramyxoviruses that do not belong to any of the seven established genera in the family Paramyxoviridae have been discovered. Amongst them are J-virus (JPV), Beilong virus (BeiPV) and Tailam virus (TlmPV), three paramyxovirus species found in rodents. Based on their similarities, it has been suggested that these viruses should compose a new genus, tentatively called 'Jeilongvirus'. Results: Here we present the complete genomes of three newly discovered paramyxoviruses, one found in a bank vole (Myodes glareolus) from Slovenia and two in a single, co-infected Rungwe brush-furred rat (Lophuromys machangui) from Mozambique, that represent three new, separate species within the putative genus 'Jeilongvirus'. The genome organization of these viruses is similar to other paramyxoviruses, but like JPV, BeiPV and TlmPV, they possess an additional open reading frame, encoding a transmembrane protein, that is located between the F and G genes. As is the case for all Jeilongviruses, the G genes of the viruses described here are unusually large, and their encoded proteins are characterized by a remarkable amino acid composition pattern that is not seen in other paramyxoviruses, but resembles certain motifs found in Orthopneumovirus G proteins. Conclusions: The phylogenetic clustering of JPV, BeiPV and TlmPV with the viruses described here, as well as their shared features that set them apart from other paramyxoviruses, provide additional support for the recognition of the genus 'Jeilongvirus'.en_US
dc.description.sponsorshipFonds Wetenschappelijk Onderzoek/Research foundation Flanders [1S28617N, 1S61618N, 1167112N, 12T1117N, 12U7118N, G066215N, G0D5117N, G0B9317N]; Slovenian Research Agency [P3-0083]; Czech Science Foundation [P506-10-0983]; European Research Council under the European Union [653316, 725422]en_US
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.urlhttps://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-018-4995-0en_US
dc.rights© The Author(s). 2018en_US
dc.subjectPMPV-1en_US
dc.subjectMMLPV-1en_US
dc.subjectMMLPV-2en_US
dc.subjectG proteinen_US
dc.subjectCell attachment proteinen_US
dc.subjectRodent paramyxovirusen_US
dc.titleDiscovery and genome characterization of three new Jeilongviruses, a lineage of paramyxoviruses characterized by their unique membrane proteinsen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Ecol & Evolutionary Biol Depten_US
dc.identifier.journalBMC GENOMICSen_US
dc.description.noteOpen access journal. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleBMC Genomics
dc.source.volume19
dc.source.issue1
refterms.dateFOA2019-01-02T17:22:19Z


Files in this item

Thumbnail
Name:
s12864-018-4995-0.pdf
Size:
1.099Mb
Format:
PDF
Description:
Final Published version

This item appears in the following Collection(s)

Show simple item record