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dc.contributor.advisorNjardarson, Jon T.
dc.contributor.authorDas, Pradipta
dc.creatorDas, Pradipta
dc.date.accessioned2019-01-10T00:36:43Z
dc.date.available2019-01-10T00:36:43Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/631472
dc.description.abstractFour new synthetic methods employing anion hopping strategy to synthesize various heterocylces are presented. In Chapter 1.A, a micro-review is presented which comprehensively cover reported reactions employing thio- and aminophosphate precursors for forming sulfur and nitrogen heterocycles. Whereas, in Chapter 1.B, a cationic and an anionic hopping cascades are reported to form 1,2,3,6-tetrahydropyridines. Origins, design, reaction, and optimizations are discussed. In Chapter 2, an asymmetric approach to assemble cis-vinyl aziridines is reported employing a strategically substituted dienolate, decorated with a γ-leaving group. Chapter 4 highlight efforts toward asymmetric total synthesis of (-)-kainic acid and (+)-α-allokainic acid. In Chapter 4A and Chapter 4B, lays the groundwork for a lithium-assisted asymmetric anion-accelerated amino-Cope rearrangement cascades in which nitrogen atom chiral auxiliary serves three critical roles, by (1) enabling in situ assembly of the chiral 3-amino-1,5-diene precursor, (2) facilitating the rearrangement via a lithium enolate chelate, and (3) imparting its influence on consecutive inter- or intramolecular C−C or C−X bond-forming events via resulting chiral enamide intermediates or imine products. Chapter 5 presents a comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction, presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.subjectAmino-Cope Rearrangement
dc.subjectAnionic Cascade
dc.subjectCombination Drugs
dc.subjectEllman Auxilliary
dc.titleDevelopment of New Anionic Hopping Cascade Routes to Synthesize Various Heterocycles
dc.typetext
dc.typeElectronic Dissertation
thesis.degree.grantorUniversity of Arizona
thesis.degree.leveldoctoral
dc.contributor.committeememberJewett, John C.
dc.contributor.committeememberGlass, Richard S.
dc.contributor.committeememberCordes, Matthew H. J
dc.description.releaseRelease after 12/11/2020
thesis.degree.disciplineGraduate College
thesis.degree.disciplineChemistry
thesis.degree.namePh.D.


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