Right ventricular afterload predicts long-term transition from parenteral to oral treprostinil in pulmonary arterial hypertension

Abstract

Despite the increasing trends, reports on long-term follow-up are limited on transitioning from parenteral to oral treprostinil therapy in patients with pulmonary arterial hypertension (PAH). We investigated both the effectiveness of parenteral to oral treprostinil transition and the characteristics associated with transition failure over a duration of two years. The study included 37 Group I functional class I and II patients with PAH on combination therapy. Patients were excluded if cardiac index <= 2.2L/min/m(2), right atrial pressure >= 11 mmHg, or 6-min walk distance 250 m. Patients were categorized as successful ((S)Transition) or unsuccessful ((U)Transition) transition based on clinical stability, or a parenteral comparator ((C)Parenteral) if they remained on parenteral therapy (no transition). All patients underwent two right heart catheterizations, one at enrollment and a second post transition. Of 24 total transition patients, 46% were classified as (U)Transition. (U)Transition occurred on average 577 days post transition. Both (U)Transition and (S)Transition had similar hemodynamics at diagnosis and treprostinil dose before and after transition. Before transition, the pulmonary vascular resistance (PVR) was significantly higher in the (U)Transition (6.7 +/- 2 WU) vs. (S)Transition group (3.5 +/- 1.5 WU). At follow-up catheterization, the (U)Transition group demonstrated further increases in PVR, greater than the (C)Parenteral group, without recovery despite "rescue" therapy in the (U)Transition group. A pre-transition PVR of 4.16 WU discriminated the (U)Transition from the (S)Transition group. While a subset of PAH patients on combination therapy may be safely transitioned from parenteral to oral treprostinil, caution should be exercised in patients with elevated baseline PVR to avoid irreversible destabilization.