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dc.contributor.authorBowen, Kate J
dc.contributor.authorRichter, Chesney K
dc.contributor.authorSkulas-Ray, Ann C
dc.contributor.authorMozaffarian, Dariush
dc.contributor.authorKris-Etherton, Penny M
dc.date.accessioned2019-03-11T20:08:31Z
dc.date.available2019-03-11T20:08:31Z
dc.date.issued2018-10-01
dc.identifier.citationBowen, K. J., Richter, C. K., Skulas‐Ray, A. C., Mozaffarian, D., & Kris‐Etherton, P. M. (2018). Projected Long‐Chain n‐3 Fatty Acid Intake Post‐Replacement of Vegetables Oils with Stearidonic Acid‐Modified Varieties: Results from a National Health and Nutrition Examination Survey 2003–2008 Analysis. Lipids, 53(10), 961-970.en_US
dc.identifier.issn1558-9307
dc.identifier.pmid30536415
dc.identifier.doi10.1002/lipd.12105
dc.identifier.urihttp://hdl.handle.net/10150/631826
dc.description.abstractEicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake is well below the amount recommended by the 2015-2020 Dietary Guidelines for Americans (0.25 g/day), supporting the need for alternative dietary sources. Stearidonic acid (SDA)-enriched soybeans were bioengineered to endogenously synthesize SDA, which can be readily metabolized to EPA in humans; thus, incorporating the derived SDA-enriched soybean oil into the food supply is a potential strategy to increase EPA. We performed a dietary modeling exercise using National Health and Nutrition Examination Survey 2003-2008 repeat 24-h dietary recall data (n = 24,621) to estimate the potential contribution of SDA-enriched oils to total long-chain n-3 fatty acid intake (defined as EPA + DHA + EPA-equivalents) following two hypothetical scenarios: (1) replacement of regular soybean oil with SDA soybean oil and (2) replacement of four common vegetable oils (corn, canola, cottonseed, and soybean) with respective SDA-modified varieties. Estimated median daily intakes increased from 0.11 to 0.16 g/day post-replacement of regular soybean oil with SDA-modified soybean oil, and to 0.21 g/day post-replacement of four oils with SDA-modified oil; the corresponding mean intakes were 0.17, 0.27, and 0.44 g/day, respectively. The percent of the population who met the 0.25 g/day recommendation increased from at least 10% to at least 30% and 40% in scenarios 1 and 2, respectively. Additional strategies are needed to ensure the majority of the US population achieve EPA and DHA recommendations, and should be assessed using methods designed to estimate the distribution of usual intake of these episodically consumed nutrients.en_US
dc.description.sponsorshipGlobal Organization for EPA and DHA Omega-3s (GOED); Haas Avocado Board; National Institutes of Health; UpToDate; Seafood Nutrition Partnership; DSM; Gates Foundation; Acasti Pharma; Astra Zeneca; Boston Heart Diagnostics; Nutrition Impact; Omada Health and Elysium Health; Pollock Communications; California Walnut Commissionen_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.rights© 2018 AOCSen_US
dc.subjectDHAen_US
dc.subjectEPAen_US
dc.subjectModified oilen_US
dc.subjectPUFAen_US
dc.subjectSDAen_US
dc.subjectn-3 fatty acidsen_US
dc.titleProjected Long-Chain n-3 Fatty Acid Intake Post-Replacement of Vegetables Oils with Stearidonic Acid-Modified Varieties: Results from a National Health and Nutrition Examination Survey 2003-2008 Analysisen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Nutr Scien_US
dc.contributor.departmentUniv Arizona, Arizona Ctr Agingen_US
dc.identifier.journalLIPIDSen_US
dc.description.note12 month embargo; published online: 7 December 2018en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleLipids


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