Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions
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Final Accepted Manuscript
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Univ Arizona, Dept Surg, Coll MedIssue Date
2018-08-01
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Dellinger, M.T. & Witte, M.H. Clin Exp Metastasis (2018) 35: 419. https://doi.org/10.1007/s10585-018-9907-9Rights
© Springer Science+Business Media B.V., part of Springer Nature 2018Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Ever since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the growth of this distinctive endothelium and its role in normal physiology and human disease. Recent technological advances have ushered in a new era of "omics" research on the lymphatic system. Research on the genome, transcriptome, proteome, and metabolome of lymphatics has increased our understanding of the biology of the lymphatic vasculature. Here, we introduce the context-lymphatic "systemomics," then briefly review some of the latest advances in research on tumor-associated lymphatic vessels highlighting several "omic" studies that have shed light on mechanisms controlling the growth and function of tumor-associated lymphatic vessels. We conclude by returning, with unanswered questions, to the larger context of cancer and the lymphatic system as a vasculature, circulation, route of entry and transport, and control center of the immune network.Note
12 month embargo; published online: 28 May 2018ISSN
1573-7276PubMed ID
29808352Version
Final accepted manuscriptAdditional Links
https://link.springer.com/article/10.1007%2Fs10585-018-9907-9ae974a485f413a2113503eed53cd6c53
10.1007/s10585-018-9907-9
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