Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions
AffiliationUniv Arizona, Dept Surg, Coll Med
MetadataShow full item record
CitationDellinger, M.T. & Witte, M.H. Clin Exp Metastasis (2018) 35: 419. https://doi.org/10.1007/s10585-018-9907-9
Rights© Springer Science+Business Media B.V., part of Springer Nature 2018
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractEver since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the growth of this distinctive endothelium and its role in normal physiology and human disease. Recent technological advances have ushered in a new era of "omics" research on the lymphatic system. Research on the genome, transcriptome, proteome, and metabolome of lymphatics has increased our understanding of the biology of the lymphatic vasculature. Here, we introduce the context-lymphatic "systemomics," then briefly review some of the latest advances in research on tumor-associated lymphatic vessels highlighting several "omic" studies that have shed light on mechanisms controlling the growth and function of tumor-associated lymphatic vessels. We conclude by returning, with unanswered questions, to the larger context of cancer and the lymphatic system as a vasculature, circulation, route of entry and transport, and control center of the immune network.
Note12 month embargo; published online: 28 May 2018
VersionFinal accepted manuscript
- Role of lymphatic vasculature in regional and distant metastases.
- Authors: Podgrabinska S, Skobe M
- Issue date: 2014 Sep
- Heterogeneity of tumor lymphangiogenesis: Progress and prospects.
- Authors: Hu X, Luo J
- Issue date: 2018 Oct
- Interaction of tumor cells and lymphatic vessels in cancer progression.
- Authors: Alitalo A, Detmar M
- Issue date: 2012 Oct 18
- Molecular biology and pathology of lymphangiogenesis.
- Authors: Karpanen T, Alitalo K
- Issue date: 2008
- IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma.
- Authors: Zhao W, Wang J, Zhu B, Duan Y, Chen F, Nian W, Sun J, Zhang B, Tong Z, Chen Z
- Issue date: 2016 Mar