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    Lymphangiogenesis, lymphatic systemomics, and cancer: context, advances and unanswered questions

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    Dellinger-Witte_CaMetast_R1.pdf
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    Description:
    Final Accepted Manuscript
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    Author
    Dellinger, Michael T
    Witte, Marlys H
    Affiliation
    Univ Arizona, Dept Surg, Coll Med
    Issue Date
    2018-08-01
    Keywords
    Cancer
    Lymphangiogenesis
    Lymphatic systemomics
    Metastasis
    Tumor lymphangiogenesis
    
    Metadata
    Show full item record
    Publisher
    SPRINGER
    Citation
    Dellinger, M.T. & Witte, M.H. Clin Exp Metastasis (2018) 35: 419. https://doi.org/10.1007/s10585-018-9907-9
    Journal
    CLINICAL & EXPERIMENTAL METASTASIS
    Rights
    © Springer Science+Business Media B.V., part of Springer Nature 2018
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Ever since it was discovered that endothelial cells line lymphatic vessels, investigators have been working on unraveling the mechanisms that control the growth of this distinctive endothelium and its role in normal physiology and human disease. Recent technological advances have ushered in a new era of "omics" research on the lymphatic system. Research on the genome, transcriptome, proteome, and metabolome of lymphatics has increased our understanding of the biology of the lymphatic vasculature. Here, we introduce the context-lymphatic "systemomics," then briefly review some of the latest advances in research on tumor-associated lymphatic vessels highlighting several "omic" studies that have shed light on mechanisms controlling the growth and function of tumor-associated lymphatic vessels. We conclude by returning, with unanswered questions, to the larger context of cancer and the lymphatic system as a vasculature, circulation, route of entry and transport, and control center of the immune network.
    Note
    12 month embargo; published online: 28 May 2018
    ISSN
    1573-7276
    PubMed ID
    29808352
    DOI
    10.1007/s10585-018-9907-9
    Version
    Final accepted manuscript
    Additional Links
    https://link.springer.com/article/10.1007%2Fs10585-018-9907-9
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10585-018-9907-9
    Scopus Count
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