PAECH, Gemma M.
SPARROW, Amy R.
Satterfield, Brieann C.
SHATTUCK, Nita L.
LAYTON, Matthew E.
Van Dongen, Hans P. A.
AffiliationUniv Arizona, Social Cognit & Affect Neurosci Lab, Dept Psychiat, Coll Med
Parasympathetic nervous system
Sympathetic nervous system
Heart rate variability
MetadataShow full item record
CitationSKORNYAKOV, E., GADDAMEEDHI, S., PAECH, G. M., SPARROW, A. R., SATTERFIELD, B. C., SHATTUCK, N. L., ... & VAN DONGEN, H. P. (2018). Cardiac autonomic activity during simulated shift work. Industrial health.
JournalBASIC AND APPLIED ECOLOGY
Rights©2019 National Institute of Occupational Safety and Health. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
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AbstractShift work leads to adverse health outcomes including increased risk of cardiovascular disease. Heart rate (HR) and heart rate variability (HRV) arc measures of cardiac autonomic activity and markers of cardiovascular disease and mortality. To investigate the effects of shift work on cardiac autonomic activity, we assessed the influence of simulated night work on HR and HRV, and dissociated the direct effects of circadian misalignment from those of sleep displacement and altered physical activity patterns. A total of 29 subjects each participated in one of two in-laboratory, simulated shift work studies. In both studies, EKG was continuously monitored via Holter monitors to measure HR and the high frequency (HF) component of HRV (HF-HRV). We found endogenous circadian rhythmicity in HR and HF-HRV. Sleep and waking physical activity, both displaced during simulated night work, had more substantial, and opposite, effects on HR and HF-HRV. Our findings show systematic but complex, interacting effects of time of day, sleep/wake state, and physical activity on cardiac autonomic activity. These effects need to be taken into account when evaluating HR and HRV in shift work settings and when interpreting these measures of cardiac autonomic activity as markers of cardiovascular disease.
NoteOpen access article
VersionFinal published version
SponsorsCollege of Pharmacy and Pharmaceutical Sciences at Washington State University; Naval Postgraduate School award [N62271-13-M-1228]; Congressionally Directed Medical Research Program [W81XWH-16-1-0319]