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    Seasonality and clinical impact of human parainfluenza viruses

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    Name:
    Maykowski_et_al-2018-Influenza ...
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    Author
    Maykowski, Philip
    Smithgall, Marie
    Zachariah, Philip
    Oberhardt, Matthew
    Vargas, Celibell
    Reed, Carrie
    Demmer, Ryan T.
    Stockwell, Melissa S.
    Saiman, Lisa
    Affiliation
    Univ Arizona, Coll Med Phoenix
    Issue Date
    2018-11
    Keywords
    epidemiology
    parainfluenza
    respiratory
    seasonality
    viruses
    
    Metadata
    Show full item record
    Publisher
    WILEY
    Citation
    Maykowski, P, Smithgall, M, Zachariah, P, et al. Seasonality and clinical impact of human parainfluenza viruses. Influenza Other Respi Viruses. 2018; 12: 706– 716. https://doi.org/10.1111/irv.12597
    Journal
    INFLUENZA AND OTHER RESPIRATORY VIRUSES
    Rights
    Published 2018. This article is a U.S. Government work and is in the public domain in the USA. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background Widespread availability of rapid diagnostic testing for respiratory viruses allows more in-depth studies of human parainfluenza viruses (HPIV). Objectives This study aimed to assess seasonality of HPIV types 1-4, clinical outcomes by HPIV type, and risk factors for illness severity. Patients/Methods This retrospective study was performed from January 2013 to December 2015 in children and adults with HPIV, detected by multiplex reverse transcription polymerase chain reaction, participating in a community surveillance study of acute respiratory infections (ARIs) in New York City and patients admitted to a tertiary care center in the same neighborhood. Seasonality trends by HPIV type were compared between the community and hospital groups. The associations between HPIV type, demographics, clinical characteristics, and illness severity were assessed. Results HPIV was detected in 69 (4%) of 1753 community surveillance participants (median age 9.2years) and 680 hospitalized patients (median age 6.8years). Seasonality for HPIV types 1-3 agreed with previously described patterns; HPIV-4 occurred annually in late summer and fall. In the community cohort, 22 (32%) participants sought medical care, 9 (13%) reported antibiotic use, and 20 (29%) reported 1day of missed work or school. Among hospitalized patients, 24% had 4 chronic conditions. Multivariable ordinal logistic regression demonstrated that increased severity of illness was significantly associated with HPIV-4 and chronic cardiovascular and respiratory conditions in children and with age 65years and chronic respiratory conditions in adults. Conclusions HPIV-4 presented late summer and early fall annually and was associated with increased severity of illness in hospitalized children.
    Note
    Open access journal.
    ISSN
    1750-2640
    1750-2659
    PubMed ID
    30051619
    DOI
    10.1111/irv.12597
    Version
    Final published version
    Sponsors
    Mobile Surveillance for ARI and ILl in the Community, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention [1UO1IP000618]
    Additional Links
    https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12597
    ae974a485f413a2113503eed53cd6c53
    10.1111/irv.12597
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