Evolutionary trends in host physiology outweigh dietary niche in structuring primate gut microbiomes
AuthorAmato, Katherine R
G Sanders, Jon
Song, Se Jin
Metcalf, Jessica L
Thompson, Luke R
Morton, James T
J McKenzie, Valerie
L Baden, Andrea
A O Britton, Gillian
P Cuozzo, Frank
Di Fiore, Anthony
J Dominy, Nathaniel
L Goldberg, Tony
Kowalewski, Martin M
J Lewis, Rebecca
L Sauther, Michelle
A White, Bryan
E Nelson, Karen
M Stumpf, Rebecca
R Leigh, Steven
AffiliationUniv Arizona, Sch Anthropol
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationAmato, K. R., Sanders, J. G., Song, S. J., Nute, M., Metcalf, J. L., Thompson, L. R., ... & Gogul, G. (2019). Evolutionary trends in host physiology outweigh dietary niche in structuring primate gut microbiomes. The ISME journal, 13(3), 576.
Rights© International Society for Microbial Ecology 2018
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractOver the past decade several studies have reported that the gut microbiomes of mammals with similar dietary niches exhibit similar compositional and functional traits. However, these studies rely heavily on samples from captive individuals and often confound host phylogeny, gut morphology, and diet. To more explicitly test the influence of host dietary niche on the mammalian gut microbiome we use 16S rRNA gene amplicon sequencing and shotgun metagenomics to compare the gut microbiota of 18 species of wild non-human primates classified as either folivores or closely related non-folivores, evenly distributed throughout the primate order and representing a range of gut morphological specializations. While folivory results in some convergent microbial traits, collectively we show that the influence of host phylogeny on both gut microbial composition and function is much stronger than that of host dietary niche. This pattern does not result from differences in host geographic location or actual dietary intake at the time of sampling, but instead appears to result from differences in host physiology. These findings indicate that mammalian gut microbiome plasticity in response to dietary shifts over both the lifespan of an individual host and the evolutionary history of a given host species is constrained by host physiological evolution. Therefore, the gut microbiome cannot be considered separately from host physiology when describing host nutritional strategies and the emergence of host dietary niches.
Note6 month embargo; published online: 11 July 2018
VersionFinal accepted manuscript
SponsorsNSF (HOMINID) ; Earth Microbiome Project (W.M. Keck Foundation) [DT061413]; John Templeton Foundation 
- The effect of captivity on the primate gut microbiome varies with host dietary niche.
- Authors: Frankel JS, Mallott EK, Hopper LM, Ross SR, Amato KR
- Issue date: 2019 Dec
- Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints.
- Authors: Gomez A, Sharma AK, Mallott EK, Petrzelkova KJ, Jost Robinson CA, Yeoman CJ, Carbonero F, Pafco B, Rothman JM, Ulanov A, Vlckova K, Amato KR, Schnorr SL, Dominy NJ, Modry D, Todd A, Torralba M, Nelson KE, Burns MB, Blekhman R, Remis M, Stumpf RM, Wilson BA, Gaskins HR, Garber PA, White BA, Leigh SR
- Issue date: 2019 Jul 31
- Multi-omics Approaches To Decipher the Impact of Diet and Host Physiology on the Mammalian Gut Microbiome.
- Authors: Milani C, Alessandri G, Mancabelli L, Mangifesta M, Lugli GA, Viappiani A, Longhi G, Anzalone R, Duranti S, Turroni F, Ossiprandi MC, van Sinderen D, Ventura M
- Issue date: 2020 Nov 10
- The gut microbiome of nonhuman primates: Lessons in ecology and evolution.
- Authors: Clayton JB, Gomez A, Amato K, Knights D, Travis DA, Blekhman R, Knight R, Leigh S, Stumpf R, Wolf T, Glander KE, Cabana F, Johnson TJ
- Issue date: 2018 Jun
- Characterization of the fecal microbiome from non-human wild primates reveals species specific microbial communities.
- Authors: Yildirim S, Yeoman CJ, Sipos M, Torralba M, Wilson BA, Goldberg TL, Stumpf RM, Leigh SR, White BA, Nelson KE
- Issue date: 2010 Nov 12