Show simple item record

dc.contributor.authorGladis, Michel-Ramirez
dc.contributor.authorRecio-Vega, Rogelio
dc.contributor.authorOcampo-Gomez, Guadalupe
dc.contributor.authorPalacios-Sanchez, Eduardo
dc.contributor.authorDelgado-Macias, Manuel
dc.contributor.authorDelgado-Gaona, Manuel
dc.contributor.authorClark Lantz, Robert
dc.contributor.authorGandolfi, Jay
dc.contributor.authorGonzalez-Cortes, Tania
dc.date.accessioned2019-04-18T18:18:54Z
dc.date.available2019-04-18T18:18:54Z
dc.date.issued2017-10-01
dc.identifier.citationMichel‐Ramirez, G., Recio‐Vega, R., Ocampo‐Gomez, G., Palacios‐Sanchez, E., Delgado‐Macias, M., Delgado‐Gaona, M., ... & Gonzalez‐Cortes, T. (2017). Association between YAP expression in neoplastic and non‐neoplastic breast tissue with arsenic urinary levels. Journal of Applied Toxicology, 37(10), 1195-1202.en_US
dc.identifier.issn1099-1263
dc.identifier.pmid28524356
dc.identifier.doi10.1002/jat.3481
dc.identifier.urihttp://hdl.handle.net/10150/632078
dc.description.abstractThe Hippo pathway regulates cell proliferation and apoptosis and it has been noted that loss of critical components of this pathway can lead to uncontrolled cell growth. Yes-associated protein (YAP) is an important component of this Hippo pathway because YAP is the nuclear effector of the Hippo tumor suppressor pathway and it is crucial for the response to oxidative stress induced by cellular process and by different xenobiotics, including arsenic. It has been proposed that YAP dysregulation can contribute to a malignant cellular phenotype acting as both a tumor suppressor and an oncogene. The aim of the study was to assess and compare the expression of YAP in neoplastic and non-neoplastic breast tissue of women chronically exposed to arsenic through drinking water. YAP expression was assessed by immunohistochemistry in 120 breast biopsies from women with breast cancer and from women with other non-neoplastic breast pathologies. Arsenic concentration was quantified in urine. The results disclosed a significant lower percentage of cytoplasm YAP expression in cases and that YAP high-intensity staining in the cytoplasm but not in the nucleus decreases the risk for breast cancer. In conclusion, our overall data suggest that YAP may act as a tumor suppressor protein because their reduced expression in cases, which can induce an environment favorable for inhibition of apoptosis and promoting cellular proliferation by increasing genetic instability of cells, which might contribute to the pathogenesis of cancer.en_US
dc.description.sponsorshipUniversity of Coahuila; Superfund National Institute of Environmental Health Sciences [NIH ES-04940]en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.rightsCopyright © 2017 John Wiley & Sons, Ltd.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectYes Associated Proteinen_US
dc.subjectYAPen_US
dc.subjectarsenicen_US
dc.subjectbreast canceren_US
dc.titleAssociation between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levelsen_US
dc.typeArticleen_US
dc.contributor.departmentUniversity of Coahuila, Torreon, Coahuila, Mexicoen_US
dc.contributor.departmentUniversity of Arizona, Tucson, AZ, USAen_US
dc.contributor.departmentUniv Arizona, Southwest Environm Hlth Sci Ctren_US
dc.contributor.departmentUniv Arizona, Dept Cellular & Mol Meden_US
dc.contributor.departmentUniv Arizona, Dept Pharmacol & Toxicolen_US
dc.identifier.journalJournal of Applied Toxicologyen_US
dc.identifier.pmcidPMC5790116
dc.description.note12 month embargo; first published: 19 May 2017en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleJournal of applied toxicology : JAT
refterms.dateFOA2018-05-19T00:00:00Z


Files in this item

Thumbnail
Name:
YAP PubMed version.pdf
Size:
88.81Kb
Format:
PDF
Description:
Final Accepted Manuscript

This item appears in the following Collection(s)

Show simple item record