Partial Sleep Deprivation Reduces the Efficacy of Orexin-A to Stimulate Physical Activity and Energy Expenditure
Name:
2017_3_DePorter_Obesity.pdf
Size:
497.5Kb
Format:
PDF
Description:
Final Accepted Manuscript
Publisher
WILEYCitation
DePorter, D. P., Coborn, J. E. and Teske, J. A. (2017), Partial Sleep Deprivation Reduces the Efficacy of Orexin‐A to Stimulate Physical Activity and Energy Expenditure. Obesity, 25: 1716-1722. doi:10.1002/oby.21944Journal
OBESITYRights
© 2017 The Obesity Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Objective: Sufficient sleep is required for weight maintenance. Sleep deprivation due to noise exposure stimulates weight gain by increasing hyperphagia and reducing energy expenditure (EE). Yet the mechanistic basis underlying the weight gain response is unclear. Orexin-A promotes arousal and negative energy balance, and orexin terminals project to the ventrolateral preoptic area (VLPO), which is involved in sleep-to-wake transitions. To determine whether sleep deprivation reduces orexin function in VLPO and to test the hypothesis that sleep deprivation would attenuate the orexin-A-stimulated increase in arousal, physical activity (PA), and EE. Methods: Electroencephalogram, electromyogram, distance traveled, and EE were determined in male Sprague-Dawley rats following orexin-A injections into VLPO both before and after acute (12-h) and chronic (8 h/d, 9 d) sleep deprivation by noise exposure. Results: Orexin-A in the VLPO significantly increased arousal, PA, total EE, and PA-related EE and reduced sleep and respiratory quotient before sleep deprivation. In contrast to after acute sleep deprivation in which orexin-A failed to stimulate EE during PA only, orexin-A failed to significantly increase arousal, PA, fat oxidation, total EE, and PA-related EE after chronic sleep deprivation. Conclusions: Sleep deprivation may reduce sensitivity to endogenous stimuli that enhance EE due to PA and thus stimulate weight gain.Note
12 month embargo; published online: 17 August 2017ISSN
1930-739XPubMed ID
28815952Version
Final accepted manuscriptAdditional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/oby.21944ae974a485f413a2113503eed53cd6c53
10.1002/oby.21944
Scopus Count
Collections
Related articles
- Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area.
- Authors: Mavanji V, Perez-Leighton CE, Kotz CM, Billington CJ, Parthasarathy S, Sinton CM, Teske JA
- Issue date: 2015 Sep 1
- Role of orexin-A in the ventrolateral preoptic area on components of total energy expenditure.
- Authors: Coborn JE, DePorter DP, Mavanji V, Sinton CM, Kotz CM, Billington CJ, Teske JA
- Issue date: 2017 Aug
- Acute partial sleep deprivation due to environmental noise increases weight gain by reducing energy expenditure in rodents.
- Authors: Parrish JB, Teske JA
- Issue date: 2017 Jan
- Sleep deprivation-induced pre- and postsynaptic modulation of orexin neurons.
- Authors: Briggs C, Bowes SC, Semba K, Hirasawa M
- Issue date: 2019 Aug
- Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation.
- Authors: Martins PJ, Marques MS, Tufik S, D'Almeida V
- Issue date: 2010 Mar