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    Partial Sleep Deprivation Reduces the Efficacy of Orexin-A to Stimulate Physical Activity and Energy Expenditure

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    2017_3_DePorter_Obesity.pdf
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    Author
    DePorter, Danielle P
    Coborn, Jamie E
    Teske, Jennifer A
    Affiliation
    Univ Arizona, Dept Nutr Sci
    Issue Date
    2017-10-01
    
    Metadata
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    Publisher
    WILEY
    Citation
    DePorter, D. P., Coborn, J. E. and Teske, J. A. (2017), Partial Sleep Deprivation Reduces the Efficacy of Orexin‐A to Stimulate Physical Activity and Energy Expenditure. Obesity, 25: 1716-1722. doi:10.1002/oby.21944
    Journal
    OBESITY
    Rights
    © 2017 The Obesity Society.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Objective: Sufficient sleep is required for weight maintenance. Sleep deprivation due to noise exposure stimulates weight gain by increasing hyperphagia and reducing energy expenditure (EE). Yet the mechanistic basis underlying the weight gain response is unclear. Orexin-A promotes arousal and negative energy balance, and orexin terminals project to the ventrolateral preoptic area (VLPO), which is involved in sleep-to-wake transitions. To determine whether sleep deprivation reduces orexin function in VLPO and to test the hypothesis that sleep deprivation would attenuate the orexin-A-stimulated increase in arousal, physical activity (PA), and EE. Methods: Electroencephalogram, electromyogram, distance traveled, and EE were determined in male Sprague-Dawley rats following orexin-A injections into VLPO both before and after acute (12-h) and chronic (8 h/d, 9 d) sleep deprivation by noise exposure. Results: Orexin-A in the VLPO significantly increased arousal, PA, total EE, and PA-related EE and reduced sleep and respiratory quotient before sleep deprivation. In contrast to after acute sleep deprivation in which orexin-A failed to stimulate EE during PA only, orexin-A failed to significantly increase arousal, PA, fat oxidation, total EE, and PA-related EE after chronic sleep deprivation. Conclusions: Sleep deprivation may reduce sensitivity to endogenous stimuli that enhance EE due to PA and thus stimulate weight gain.
    Note
    12 month embargo; published online: 17 August 2017
    ISSN
    1930-739X
    PubMed ID
    28815952
    DOI
    10.1002/oby.21944
    Version
    Final accepted manuscript
    Additional Links
    https://onlinelibrary.wiley.com/doi/full/10.1002/oby.21944
    ae974a485f413a2113503eed53cd6c53
    10.1002/oby.21944
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