A preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single-arm pilot study
AuthorWeihs, Karen L.
McConnell, Mairead H.
Wiley, Joshua F.
Crespi, Catherine M.
Stanton, Annette L.
AffiliationUniv Arizona, Dept Psychiat
Univ Arizona, Dept Psychol
MetadataShow full item record
CitationWeihs, K. L., McConnell, M. H., Wiley, J. F., Crespi, C. M., Sauer‐Zavala, S., & Stanton, A. L. (2019). A preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single‐arm pilot study. Psycho‐Oncology.
Rights© 2019 John Wiley & Sons, Ltd.
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AbstractObjective Apply the National Institutes of Health (NIH) Stage Model to design and test an intervention to prevent depression in breast cancer patients at risk for depression. Methods We identified mindful emotion awareness, along with approach and avoidance strategies for cancer-related coping and emotion regulation, as targets for a preventive intervention adapted from the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders. Patients' preferences for individual, in-person, and time-efficient sessions informed the design. Patients at risk for depression received a 6-week, 5-hour intervention with daily exercises. Intervention targets were assessed at baseline, before each session, and 4-weeks post intervention. Mixed effects analysis of variance (ANOVA) assessed change over the follow-up period, controlling for age, partnered status, and disease stage. Results Fifty-five percent (40/72) of women screened within 6 months of diagnosis had elevated depression risk. Of these, 24 (60%) signed consent. Sixteen received intervention after five were excluded for current depressive disorder, cognitive impairment, or death. Three dropped out. Ninety-eight percent attendance and 77% practice days indicated feasibility. Effect sizes (Cohen's d) corrected for regression to the mean (RTM) were 0.82 for cancer-related acceptance coping, 0.65 for cancer-related emotional expression, and 0.32 and 0.42 for decreased cancer-related avoidance coping and depressive symptoms, respectively. Effect sizes for variables lacking data to correct for RTM were 1.0, 0.7, and 0.5 for decreased rumination, experiential avoidance, and fear of depression, respectively, and 1.3, 0.6, and 0.4 for increased cognitive flexibility, distress tolerance, and describing/not judging emotions, respectively. Conclusions The feasibility of this intervention and malleability of its targets support its further investigation.
Note12 month embargo; first published: 25 February 2019
VersionFinal accepted manuscript
SponsorsBreast Cancer Research Fund ; National Cancer Institute [NIH R01 CA133081, NCI-NIH P30 CA 16042, NCI-NIH P30CA023074]