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dc.contributor.authorWeihs, Karen L.
dc.contributor.authorMcConnell, Mairead H.
dc.contributor.authorWiley, Joshua F.
dc.contributor.authorCrespi, Catherine M.
dc.contributor.authorSauer-Zavala, Shannon
dc.contributor.authorStanton, Annette L.
dc.date.accessioned2019-04-27T00:17:57Z
dc.date.available2019-04-27T00:17:57Z
dc.date.issued2019-04
dc.identifier.citationWeihs, K. L., McConnell, M. H., Wiley, J. F., Crespi, C. M., Sauer‐Zavala, S., & Stanton, A. L. (2019). A preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single‐arm pilot study. Psycho‐Oncology.en_US
dc.identifier.issn1057-9249
dc.identifier.issn1099-1611
dc.identifier.doi10.1002/pon.v28.4
dc.identifier.urihttp://hdl.handle.net/10150/632136
dc.description.abstractObjective Apply the National Institutes of Health (NIH) Stage Model to design and test an intervention to prevent depression in breast cancer patients at risk for depression. Methods We identified mindful emotion awareness, along with approach and avoidance strategies for cancer-related coping and emotion regulation, as targets for a preventive intervention adapted from the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders. Patients' preferences for individual, in-person, and time-efficient sessions informed the design. Patients at risk for depression received a 6-week, 5-hour intervention with daily exercises. Intervention targets were assessed at baseline, before each session, and 4-weeks post intervention. Mixed effects analysis of variance (ANOVA) assessed change over the follow-up period, controlling for age, partnered status, and disease stage. Results Fifty-five percent (40/72) of women screened within 6 months of diagnosis had elevated depression risk. Of these, 24 (60%) signed consent. Sixteen received intervention after five were excluded for current depressive disorder, cognitive impairment, or death. Three dropped out. Ninety-eight percent attendance and 77% practice days indicated feasibility. Effect sizes (Cohen's d) corrected for regression to the mean (RTM) were 0.82 for cancer-related acceptance coping, 0.65 for cancer-related emotional expression, and 0.32 and 0.42 for decreased cancer-related avoidance coping and depressive symptoms, respectively. Effect sizes for variables lacking data to correct for RTM were 1.0, 0.7, and 0.5 for decreased rumination, experiential avoidance, and fear of depression, respectively, and 1.3, 0.6, and 0.4 for increased cognitive flexibility, distress tolerance, and describing/not judging emotions, respectively. Conclusions The feasibility of this intervention and malleability of its targets support its further investigation.en_US
dc.description.sponsorshipBreast Cancer Research Fund [20184915]; National Cancer Institute [NIH R01 CA133081, NCI-NIH P30 CA 16042, NCI-NIH P30CA023074]en_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/toc/10991611/28/4en_US
dc.rights© 2019 John Wiley & Sons, Ltd.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectbreast canceren_US
dc.subjectcopingen_US
dc.subjectdepressionen_US
dc.subjectinterventionen_US
dc.subjectoncologyen_US
dc.subjectpreventionen_US
dc.titleA preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single-arm pilot studyen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Psychiaten_US
dc.contributor.departmentUniv Arizona, Dept Psycholen_US
dc.identifier.journalPSYCHO-ONCOLOGYen_US
dc.description.note12 month embargo; first published: 25 February 2019en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitlePsycho-Oncology
dc.source.volume28
dc.source.issue4


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