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    Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications

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    NanoMed18_38.pdf
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    Final Accepted Manuscript
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    Author
    Frost, Timothy S.
    Jiang, Linan
    Zohar, Yitshak
    Affiliation
    Univ Arizona
    Issue Date
    2018
    Keywords
    protein transport
    convection-diffusion flow
    A549 cell line
    pharmacokinetics
    
    Metadata
    Show full item record
    Publisher
    IEEE
    Citation
    Frost, T. S., Jiang, L., & Zohar, Y. (2018, December). Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications. In 2018 IEEE 12th International Conference on Nano/Molecular Medicine and Engineering (NANOMED) (pp. 27-30). IEEE.
    Journal
    2018 IEEE 12TH INTERNATIONAL CONFERENCE ON NANO/MOLECULAR MEDICINE AND ENGINEERING (IEEE - NANOMED)
    Rights
    © 2018 IEEE.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Transport of three different molecules across a porous membrane, with and without a confluent A549 cell monolayer, has been investigated in Transwells and microfluidic devices. The A549 cell line was selected since it has extensively been utilized in toxicology studies due to its potential target for drug delivery of macro molecules. The measured molecular transport rate was found to decrease with increasing molecular size due to lower diffusivity. The confluent cell monolayer presents a barrier to molecular, significantly reducing the transport rate of larger molecules with little effect on the paracellular transport of smaller molecules. The results indicate that the microfluidic system is a good model for pharmacokinetic applications.
    ISSN
    978-1-5386-7579-3
    DOI
    10.1109/NANOMED.2018.8641558
    Version
    Final accepted manuscript
    Sponsors
    Arizona Biomedical Research Commission [ABRC ADHS14-082983]; NASA Space Grant Undergraduate Internship
    Additional Links
    https://ieeexplore.ieee.org/document/8641558/
    ae974a485f413a2113503eed53cd6c53
    10.1109/NANOMED.2018.8641558
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