Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003-2004
da Silva, Vanessa
Thomson, Cynthia A
Burgess, Jefferey L
O'Rourke, Mary Kay
Harris, Robin B
AffiliationUniv Arizona, Coll Med, Dept Pediat
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth
Univ Arizona, Dept Nutr Sci, Coll Agr & Life Sci
Univ Arizona, Ctr Canc
MetadataShow full item record
PublisherELSEVIER SCIENCE BV
CitationKurzius-Spencer, M., da Silva, V., Thomson, C. A., Hartz, V., Hsu, C. H., Burgess, J. L., ... & Harris, R. B. (2017). Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. Science of the Total Environment, 607, 381-390.
JournalSCIENCE OF THE TOTAL ENVIRONMENT
Rights© 2017 Elsevier B.V. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractExposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure. Univariate and multivariable regression models were used to evaluate the relationship of dietary and blood nutrients to urinary As methylation in the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Outcome variables were the percent of the sum of inAs and methylated As species (inAs + MMA + DMA) excreted as inAs, MMA, and DMA, and the ratio of MMA: DMA. In univariate models, dietary folate, vitamin B6 and protein intake were associated with lower urinary inAs% and greater DMA% in adults (>= 18 years), with similar trends in children (6-18). In adjusted models, vitamin B6 intake (p=0.011) and RBC folate (p=0.036) were associated with lower inAs%, while dietary vitamin B12 was associated with higher inAs% (p=0.002) and lower DMA% (p=0.030). Total plasma homocysteine was associated with higher MMA% (p=0.004) and lower DMA% (p=0.003), but notwith inAs%; other blood nutrients showed no association with urinary As. Although effect size is small, these findings suggest that 1C nutrients can influence inAs methylation and potentially play an indirect role in reducing toxicity in a general population sample. (C) 2017 Elsevier B.V. All rights reserved.
Note24 month embargo; published online: 27 July 2017
VersionFinal accepted manuscript
SponsorsU.S. Environmental Protection Agency (EPA) Star Grant [R83399201-0]; University of Arizona Specialized Program of Research Excellence (SPORE) (NIH/NCI) [CA95060]; Southwest Environmental Health Sciences Center Career Development Award [S006694/ES/NIEHSNIH]
- Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh.
- Authors: Heck JE, Gamble MV, Chen Y, Graziano JH, Slavkovich V, Parvez F, Baron JA, Howe GR, Ahsan H
- Issue date: 2007 May
- Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh.
- Authors: Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich V, Parvez F, Chen Y, Levy D, Factor-Litvak P, Graziano JH
- Issue date: 2006 Nov
- Dietary intake and arsenic methylation in a U.S. population.
- Authors: Steinmaus C, Carrigan K, Kalman D, Atallah R, Yuan Y, Smith AH
- Issue date: 2005 Sep
- Methylation study of a population environmentally exposed to arsenic in drinking water.
- Authors: Hopenhayn-Rich C, Biggs ML, Smith AH, Kalman DA, Moore LE
- Issue date: 1996 Jun
- Creatinine, diet, micronutrients, and arsenic methylation in West Bengal, India.
- Authors: Basu A, Mitra S, Chung J, Guha Mazumder DN, Ghosh N, Kalman D, von Ehrenstein OS, Steinmaus C, Liaw J, Smith AH
- Issue date: 2011 Sep