Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative
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Analgesic use and risk of recurrent ...
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Final Accepted Manuscript
Author
Lo-Ciganic, W.-H.Floden, L.
Lee, J.K.
Ashbeck, E.L.
Zhou, L.
Chinthammit, C.
Purdy, A.W.
Kwoh, C.K.
Affiliation
Univ Arizona, Coll Pharm, Dept Pharm Practice & SciUniv Arizona, Coll Med, Arthrit Ctr
Univ Arizona, Div Rheumatol, Dept Med
Issue Date
2017-09Keywords
AnalgesicsOpioids
Antidepressants
Non-steroidal anti-inflammatory drugs
Falls
Knee osteoarthritis
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ELSEVIER SCI LTDCitation
Lo-Ciganic, W. H., Floden, L., Lee, J. K., Ashbeck, E. L., Zhou, L., Chinthammit, C., ... & Kwoh, C. K. (2017). Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis and cartilage, 25(9), 1390-1398.Journal
OSTEOARTHRITIS AND CARTILAGERights
© 2017 Osteoarthritis Research Society International; published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Objective: Few studies have compared the risk of recurrent falls across different types of analgesic use, and with limited adjustment for potential confounders (e.g., pain/depression severity). We assessed analgesic use and the subsequent risk of recurrent falls, among participants with or at risk of knee osteoarthritis (OA). Methods: A longitudinal analysis included 4231 participants aged 45-79 years at baseline with 4-year follow-up from the Osteoarthritis Initiative (OAI) cohort study. We grouped participants into six mutually exclusive subgroups based on annually assessed analgesic use in the following hierarchical order of analgesic/central nervous system (CNS) potency: use of (1) opioids, (2) antidepressants, (3) other prescription pain medications, (4) over-the-counter (OTC) pain medications, (5) nutraceuticals, and (6) no analgesics. We used multivariable modified Poisson regression models with a robust error variance to estimate the effect of analgesic use on the risk of recurrent falls (>= 2) in the following year, adjusted for demographics and health status/behavior factors. Results: Opioid use increased from 2.7% at baseline to 3.6% at the 36-month visit (>80% using other analgesics/nutraceuticals), while other prescription pain medication use decreased from 16.7% to 11.9% over this time period. Approximately 15% of participants reported recurrent falls. Compared to those not using analgesics, participants who used opioids and/or antidepressants had a 22-25% increased risk of recurrent falls (opioids: RRadjusted = 1.22, 95% CI = 1.04-1.45; antidepressants: RRadjusted = 1.25, 95% CI = 1.10-1.41). Conclusion: Participants with or at risk of knee OA who used opioids and antidepressants with/without other analgesics/nutraceuticals may have an increased risk of recurrent falls after adjusting for potential confounders. Use of opioids and antidepressants warrants caution. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.Description
12 month embargo; available online 4 April 2017.ISSN
10634584Version
Final accepted manuscriptSponsors
University of Arizona Health Sciences Career Development Award; National Institutes of Health, a branch of the Department of Health and Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262]; Merck Research Laboratories; Novartis Pharmaceuticals Corporation; GlaxoSmithKline; Pfizer, Inc.; Foundation for the National Institutes of HealthAdditional Links
https://linkinghub.elsevier.com/retrieve/pii/S106345841730938Xae974a485f413a2113503eed53cd6c53
10.1016/j.joca.2017.03.017