Show simple item record

dc.contributor.authorLo-Ciganic, W.-H.
dc.contributor.authorFloden, L.
dc.contributor.authorLee, J.K.
dc.contributor.authorAshbeck, E.L.
dc.contributor.authorZhou, L.
dc.contributor.authorChinthammit, C.
dc.contributor.authorPurdy, A.W.
dc.contributor.authorKwoh, C.K.
dc.date.accessioned2019-04-30T20:08:01Z
dc.date.available2019-04-30T20:08:01Z
dc.date.issued2017-09
dc.identifier.citationLo-Ciganic, W. H., Floden, L., Lee, J. K., Ashbeck, E. L., Zhou, L., Chinthammit, C., ... & Kwoh, C. K. (2017). Analgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis and cartilage, 25(9), 1390-1398.en_US
dc.identifier.issn10634584
dc.identifier.doi10.1016/j.joca.2017.03.017
dc.identifier.urihttp://hdl.handle.net/10150/632163
dc.description12 month embargo; available online 4 April 2017.en_US
dc.description.abstractObjective: Few studies have compared the risk of recurrent falls across different types of analgesic use, and with limited adjustment for potential confounders (e.g., pain/depression severity). We assessed analgesic use and the subsequent risk of recurrent falls, among participants with or at risk of knee osteoarthritis (OA). Methods: A longitudinal analysis included 4231 participants aged 45-79 years at baseline with 4-year follow-up from the Osteoarthritis Initiative (OAI) cohort study. We grouped participants into six mutually exclusive subgroups based on annually assessed analgesic use in the following hierarchical order of analgesic/central nervous system (CNS) potency: use of (1) opioids, (2) antidepressants, (3) other prescription pain medications, (4) over-the-counter (OTC) pain medications, (5) nutraceuticals, and (6) no analgesics. We used multivariable modified Poisson regression models with a robust error variance to estimate the effect of analgesic use on the risk of recurrent falls (>= 2) in the following year, adjusted for demographics and health status/behavior factors. Results: Opioid use increased from 2.7% at baseline to 3.6% at the 36-month visit (>80% using other analgesics/nutraceuticals), while other prescription pain medication use decreased from 16.7% to 11.9% over this time period. Approximately 15% of participants reported recurrent falls. Compared to those not using analgesics, participants who used opioids and/or antidepressants had a 22-25% increased risk of recurrent falls (opioids: RRadjusted = 1.22, 95% CI = 1.04-1.45; antidepressants: RRadjusted = 1.25, 95% CI = 1.10-1.41). Conclusion: Participants with or at risk of knee OA who used opioids and antidepressants with/without other analgesics/nutraceuticals may have an increased risk of recurrent falls after adjusting for potential confounders. Use of opioids and antidepressants warrants caution. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.en_US
dc.description.sponsorshipUniversity of Arizona Health Sciences Career Development Award; National Institutes of Health, a branch of the Department of Health and Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, N01-AR-2-2262]; Merck Research Laboratories; Novartis Pharmaceuticals Corporation; GlaxoSmithKline; Pfizer, Inc.; Foundation for the National Institutes of Healthen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S106345841730938Xen_US
dc.rights© 2017 Osteoarthritis Research Society International; published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.en_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subjectAnalgesicsen_US
dc.subjectOpioidsen_US
dc.subjectAntidepressantsen_US
dc.subjectNon-steroidal anti-inflammatory drugsen_US
dc.subjectFallsen_US
dc.subjectKnee osteoarthritisen_US
dc.titleAnalgesic use and risk of recurrent falls in participants with or at risk of knee osteoarthritis: data from the Osteoarthritis Initiativeen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Pharm, Dept Pharm Practice & Scien_US
dc.contributor.departmentUniv Arizona, Coll Med, Arthrit Ctren_US
dc.contributor.departmentUniv Arizona, Div Rheumatol, Dept Meden_US
dc.identifier.journalOSTEOARTHRITIS AND CARTILAGEen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleOsteoarthritis and Cartilage
dc.source.volume25
dc.source.issue9
dc.source.beginpage1390
dc.source.endpage1398
refterms.dateFOA2018-04-04T00:00:00Z


Files in this item

Thumbnail
Name:
Analgesic use and risk of recurrent ...
Size:
502.9Kb
Format:
PDF
Description:
Final Accepted Manuscript

This item appears in the following Collection(s)

Show simple item record