In utero and early childhood exposure to arsenic decreases lung function in children
Lantz, R Clark
Gandolfi, A Jay
Gonzalez-De Alba, Cesar
AffiliationUniv Arizona, Dept Cellular & Mol Med
Univ Arizona, Southwest Environm Hlth Sci Ctr
Univ Arizona, Dept Pharmacol & Toxicol
MetadataShow full item record
CitationRecio‐Vega, R., Gonzalez‐Cortes, T., Olivas‐Calderon, E., Lantz, R. C., Gandolfi, A. J., & Alba, C. G. D. (2015). In utero and early childhood exposure to arsenic decreases lung function in children. Journal of Applied Toxicology, 35(4), 358-366.
JournalJOURNAL OF APPLIED TOXICOLOGY
RightsCopyright © 2014 John Wiley & Sons, Ltd.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractThe lung is a target organ for adverse health outcomes following exposure to As. Several studies have reported a high prevalence of respiratory symptoms and diseases in subjects highly exposed to As through drinking water; however, most studies to date has been performed in exposed adults, with little information on respiratory effects in children. The objective of the study was to evaluate the association between urinary levels of As and its metabolites with lung function in children exposed in utero and in early childhood to high As levels through drinking water. A total of 358 healthy children were included in our study. Individual exposure was assessed based on urinary concentration of inorganic As. Lung function was assessed by spirometry. Participants were exposed since pregnancy until early childhood to an average water As concentration of 152.13 µg l⁻¹. The mean urinary As level registered in the studied subjects was 141.2 µg l⁻¹ and only 16.7% had a urinary concentration below the national concern level. Forced vital capacity was significantly decreased in the studied population and it was negatively associated with the percentage of inorganic As. More than 57% of the subjects had a restrictive spirometric pattern. The urinary As level was higher in those children with restrictive lung patterns when compared with the levels registered in subjects with normal spirometric patterns. Exposure to As through drinking water during in utero and early life was associated with a decrease in forced vital capacity and with a restrictive spirometric pattern in the children evaluated.
Note12 month embargo; published online in Wiley Online Library: 15 August 2014
VersionFinal accepted manuscript
SponsorsThis work was supported in part by the University of Coahuila and by the Superfund National Institute of Environmental Health Sciences (grant number ES-04940).
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