Incident atrial fibrillation and the risk of fracture in the cardiovascular health study
AuthorWallace, E R
Siscovick, D S
Sitlani, C M
Robbins, J A
Fink, H A
Cauley, J A
Heckbert, S R
MetadataShow full item record
PublisherSPRINGER LONDON LTD
CitationSiscovick, D., Dublin, S., Fink, H., Heckbert, S., Wallace, E., Sitlani, C., ... & Carbone, L. (2017). Incident atrial fibrillation and the risk of fracture in the cardiovascular health study. Osteoporosis International, 28(2).
Rights© International Osteoporosis Foundation and National Osteoporosis Foundation 2016.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractIn this prospective cohort of 4462 older adults, incident atrial fibrillation (AF) was not statistically significantly associated with subsequent risk of incident fracture. AF is associated with stroke, heart failure, dementia, and death, but its association with fracture is unknown. Therefore, we examined the association of incident AF with the risk of subsequent fracture in the Cardiovascular Health Study (CHS) cohort. Of the CHS participants aged ae<yen>65 years, 4462 were followed between 1991 and 2009, mean follow-up 8.8 years. Incident AF was identified by annual study electrocardiogram (ECG), hospital discharge diagnosis codes, or Medicare claims. Fractures of the hip, distal forearm, humerus, or pelvis were identified using hospital discharge diagnosis codes or Medicare claims. We used Cox proportional hazard models to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association between incident AF (time-varying) and the risk of subsequent fracture. We also evaluated whether AF was associated with risk of sustaining a fall. Crude incident fracture rate was 22.9 per 1000 person-years in participants with AF and 17.7 per 1000 person-years in participants without AF. Individuals with incident AF were not at significantly higher risk of hip fracture (adjusted HR = 1.09, 95 % CI 0.83-1.42) or fracture at any selected site (adjusted HR = 0.97, 95 % CI 0.77-1.22) or risk of sustaining a fall (adjusted HR = 1.00, 95 % CI = 0.87-1.16) compared with those without AF. In this cohort of older, community-dwelling adults, incident AF was not shown to be associated with falls or hip or other fractures.
Note12 month embargo; first Online: 07 October 2016
VersionFinal accepted manuscript
SponsorsNational Heart, Lung, and Blood Institute (NHLBI) [HHSN268201200036C, HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, HL080295, HL102214]; National Institute on Aging (NIA) [AG023629]; NHLBI [I-T32-HL07902]
- Atrial fibrillation and risk of hip fracture: A population-based analysis of 113,600 individuals.
- Authors: Wong CX, Gan SW, Lee SW, Gallagher C, Kinnear NJ, Lau DH, Mahajan R, Roberts-Thomson KC, Sanders P
- Issue date: 2017 Sep 15
- Soluble CD14 and fracture risk.
- Authors: Bethel M, Bůžková P, Fink HA, Robbins JA, Cauley JA, Lee J, Barzilay JI, Jalal DI, Carbone LD
- Issue date: 2016 May
- Incident Atrial Fibrillation and Disability-Free Survival in the Cardiovascular Health Study.
- Authors: Wallace ER, Siscovick DS, Sitlani CM, Dublin S, Mitchell PH, Odden MC, Hirsch CH, Thielke S, Heckbert SR
- Issue date: 2016 Apr
- Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation.
- Authors: Lau WC, Chan EW, Cheung CL, Sing CW, Man KK, Lip GY, Siu CW, Lam JK, Lee AC, Wong IC
- Issue date: 2017 Mar 21
- Serial measures of cardiac troponin T levels by a highly sensitive assay and incident atrial fibrillation in a prospective cohort of ambulatory older adults.
- Authors: Hussein AA, Bartz TM, Gottdiener JS, Sotoodehnia N, Heckbert SR, Lloyd-Jones D, Kizer JR, Christenson R, Wazni O, deFilippi C
- Issue date: 2015 May