Upstream Regulators of TORC1 Signaling Pathway in Saccharomyces cerevisiae
Issue Date
2019Keywords
cell and molecular biologyAdvisor
Capaldi, AndrewMetadata
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The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
Many nutrients including glucose, phosphate and amino acids regulate TORC1 activity and when the cells are in stress or starvation conditions, TORC1 activity is inhibited. It remains unclear how this happens. So, we are interested in mapping the signaling system that talks to TORC1 to ultimately understand how the complex integrates signals to control growth in stress conditions. In this project, the response of TORC1 under nitrogen, glucose and phosphate starvation conditions was checked in strains lacking one or more stress signaling pathway proteins to identify the mechanism which leads to inhibition of TORC1 in stress conditions.Type
textElectronic Report
Degree Name
P.S.M.Degree Level
mastersDegree Program
Graduate CollegeApplied Biosciences