Changes in Functional Connectivity following Treatment with Emotion Regulation Therapy
AuthorScult, Matthew A.
Fresco, David Marc
AffiliationUniv Arizona, Dept Psychol
Keywordsgeneralized anxiety disorder
major depressive disorder
resting state functional connectivity
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationScult MA, Fresco DM, Gunning FM, Liston C, Seeley SH, García E and Mennin DS (2019) Changes in Functional Connectivity Following Treatment With Emotion Regulation Therapy. Front. Behav. Neurosci. 13:10. doi: 10.3389/fnbeh.2019.00010
Rights© 2019 Scult, Fresco, Gunning, Liston, Seeley, García and Mennin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractEmotion regulation therapy (ERT) is an efficacious treatment for distress disorders (i.e., depression and anxiety), predicated on a conceptual model wherein difficult to treat distress arises from intense emotionality (e.g., neuroticism, dispositional negativity) and is prolonged by negative self-referentiality (e.g., worry, rumination). Individuals with distress disorders exhibit disruptions in two corresponding brain networks including the salience network (SN) reflecting emotion/motivation and the default mode network (DMN) reflecting self-referentiality. Using resting-state functional connectivity (rsFC) analyses, seeded with primary regions in each of these networks, we investigated whether ERT was associated with theoretically consistent changes across nodes of these networks and whether these changes related to improvements in clinical outcomes. This study examined 21 generalized anxiety disorder (GAD) patients [with and without major depressive disorder (MDD)] drawn from a larger intervention trial (Renna et al., 2018a), who completed resting state fMRI scans before and after receiving 16 sessions of ERT. We utilized seed-based connectivity analysis with seeds in the posterior cingulate cortex (PCC), right anterior insula, and right posterior insula, to investigate whether ERT was associated with changes in connectivity of nodes of the DMN and SN networks to regions across the brain. Findings revealed statistically significant treatment linked changes in both the DMN and SN network nodes, and these changes were associated with clinical improvement corresponding to medium effect sizes. The results are discussed in light of a nuanced understanding of the role of connectivity changes in GAD and MDD, and begin to provide neural network support for the hypothesized treatment model predicated by ERT.
NoteOpen access journal
VersionFinal published version
SponsorsCUNY Collaborative Incentive Research Grant (CIRG) ; PSC-CUNY Enhanced Research Award [65797-0043]; National Institutes of Health (NIH) MBRS-RISE Program at Hunter College [GM060665]; Doctoral Student Research Grant, City University of New York, Graduate Center; NIH [1R01HL119977, 1P30NR015326, 1R61AT009867]