n-3 Docosapentaenoic Acid Intake and Relationship with Plasma Long-Chain n-3 Fatty Acid Concentrations in the United States: NHANES 2003-2014
Name:
Richter_et_al._NHANES_DPA_manu ...
Size:
386.0Kb
Format:
PDF
Description:
Final Accepted Manuscript
Author
Richter, Chesney KBisselou, Karl Stessy
Nordgren, Tara M
Smith, Lynette
Appiah, Adams Kusi
Hein, Nicholas
Anderson-Berry, Ann
Kris-Etherton, Penny
Hanson, Corrine
Skulas-Ray, Ann C
Affiliation
Univ Arizona, Dept Nutr SciIssue Date
2019-04-01
Metadata
Show full item recordPublisher
WILEYCitation
Richter, C. K., Bisselou, K. S., Nordgren, T. M., Smith, L. , Appiah, A. K., Hein, N. , Anderson‐Berry, A. , Kris‐Etherton, P. , Hanson, C. and Skulas‐Ray, A. C. (2019), n‐3 Docosapentaenoic Acid Intake and Relationship with Plasma Long‐Chain n‐3 Fatty Acid Concentrations in the United States: NHANES 2003–2014. Lipids, 54: 221-230. doi:10.1002/lipd.12146Journal
LIPIDSRights
© 2019 AOCS.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The long-chain n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a crucial role in health, but previous National Health and Nutrition Examination Survey (NHANES) analyses have shown that EPA and DHA intake in the United States is far below recommendations (similar to 250-500 mg/day EPA + DHA). Less is known about docosapentaenoic acid (DPA), the metabolic intermediate of EPA and DHA; however, evidence suggests DPA may be an important contributor to long-chain n-3 fatty acid intake and impart unique benefits. We used NHANES 2003-2014 data (n = 45,347) to assess DPA intake and plasma concentrations, as well as the relationship between intake and plasma concentrations of EPA, DPA, and DHA. Mean DPA intake was 22.3 +/- 0.8 mg/day from 2013 to 2014, and increased significantly over time (p < 0.001), with the lowest values from 2003 to 2004 (16.2 +/- 1.2 mg/day). DPA intake was higher in adults (20-55 years) and seniors (55+ years) compared to younger individuals. In regression analyses, DPA intake was a significant predictor of plasma EPA (beta = 138.5; p < 0.001) and DHA (beta = 318.9; p < 0.001). Plasma DPA was predicted by EPA and DHA intake (beta = 13.15; p = 0.001 and beta = 7.4; p = 0.002), but not dietary DPA (p = 0.3). This indicates that DPA intake is not a good marker of plasma DPA status (or vice versa), and further research is needed to understand the factors that affect the interconversion of EPA and DPA. These findings have implications for future long-chain n-3 fatty acids dietary recommendations.Note
12 month embargo; published online: 26 April 2019ISSN
1558-9307PubMed ID
31025717Version
Final accepted manuscriptAdditional Links
https://aocs.onlinelibrary.wiley.com/doi/full/10.1002/lipd.12146ae974a485f413a2113503eed53cd6c53
10.1002/lipd.12146
Scopus Count
Collections
Related articles
- Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid.
- Authors: Markworth JF, Kaur G, Miller EG, Larsen AE, Sinclair AJ, Maddipati KR, Cameron-Smith D
- Issue date: 2016 Nov
- Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men.
- Authors: Burdge GC, Finnegan YE, Minihane AM, Williams CM, Wootton SA
- Issue date: 2003 Aug
- (n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?
- Authors: Mozaffarian D, Wu JH
- Issue date: 2012 Mar
- Different metabolism of EPA, DPA and DHA in humans: A double-blind cross-over study.
- Authors: Guo XF, Tong WF, Ruan Y, Sinclair AJ, Li D
- Issue date: 2020 Jul
- Pure omega 3 polyunsaturated fatty acids (EPA, DPA or DHA) are associated with increased plasma levels of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) in a short-term study in women.
- Authors: Liu G, Gibson RA, Callahan D, Guo XF, Li D, Sinclair AJ
- Issue date: 2020 Mar 1