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    n-3 Docosapentaenoic Acid Intake and Relationship with Plasma Long-Chain n-3 Fatty Acid Concentrations in the United States: NHANES 2003-2014

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    Name:
    Richter_et_al._NHANES_DPA_manu ...
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    Description:
    Final Accepted Manuscript
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    Author
    Richter, Chesney K
    Bisselou, Karl Stessy
    Nordgren, Tara M
    Smith, Lynette
    Appiah, Adams Kusi
    Hein, Nicholas
    Anderson-Berry, Ann
    Kris-Etherton, Penny
    Hanson, Corrine
    Skulas-Ray, Ann C
    Affiliation
    Univ Arizona, Dept Nutr Sci
    Issue Date
    2019-04-01
    Keywords
    Docosahexaenoic acid
    Eicosapentaenoic acid
    Fish oil supplements
    Oily fish
    Omega-3 fatty acids
    
    Metadata
    Show full item record
    Publisher
    WILEY
    Citation
    Richter, C. K., Bisselou, K. S., Nordgren, T. M., Smith, L. , Appiah, A. K., Hein, N. , Anderson‐Berry, A. , Kris‐Etherton, P. , Hanson, C. and Skulas‐Ray, A. C. (2019), n‐3 Docosapentaenoic Acid Intake and Relationship with Plasma Long‐Chain n‐3 Fatty Acid Concentrations in the United States: NHANES 2003–2014. Lipids, 54: 221-230. doi:10.1002/lipd.12146
    Journal
    LIPIDS
    Rights
    © 2019 AOCS.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The long-chain n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), play a crucial role in health, but previous National Health and Nutrition Examination Survey (NHANES) analyses have shown that EPA and DHA intake in the United States is far below recommendations (similar to 250-500 mg/day EPA + DHA). Less is known about docosapentaenoic acid (DPA), the metabolic intermediate of EPA and DHA; however, evidence suggests DPA may be an important contributor to long-chain n-3 fatty acid intake and impart unique benefits. We used NHANES 2003-2014 data (n = 45,347) to assess DPA intake and plasma concentrations, as well as the relationship between intake and plasma concentrations of EPA, DPA, and DHA. Mean DPA intake was 22.3 +/- 0.8 mg/day from 2013 to 2014, and increased significantly over time (p < 0.001), with the lowest values from 2003 to 2004 (16.2 +/- 1.2 mg/day). DPA intake was higher in adults (20-55 years) and seniors (55+ years) compared to younger individuals. In regression analyses, DPA intake was a significant predictor of plasma EPA (beta = 138.5; p < 0.001) and DHA (beta = 318.9; p < 0.001). Plasma DPA was predicted by EPA and DHA intake (beta = 13.15; p = 0.001 and beta = 7.4; p = 0.002), but not dietary DPA (p = 0.3). This indicates that DPA intake is not a good marker of plasma DPA status (or vice versa), and further research is needed to understand the factors that affect the interconversion of EPA and DPA. These findings have implications for future long-chain n-3 fatty acids dietary recommendations.
    Note
    12 month embargo; published online: 26 April 2019
    ISSN
    1558-9307
    PubMed ID
    31025717
    DOI
    10.1002/lipd.12146
    Version
    Final accepted manuscript
    Additional Links
    https://aocs.onlinelibrary.wiley.com/doi/full/10.1002/lipd.12146
    ae974a485f413a2113503eed53cd6c53
    10.1002/lipd.12146
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