Two-stage study of lung cancer risk modification by a functional variant in the 3 '-untranslated region of SMAD5 based on the bone morphogenetic protein pathway
Author
Zhang, ZiliWang, Jian
Zeng, Xiansheng
Li, Defu
Ding, Mingjing
Guan, Ruijuan
Yuan, Liang
Zhou, Qipeng
Guo, Meihua
Xiong, Mingmei
Dong, Lian
Lu, Wenju
Affiliation
Univ Arizona, Dept Med, Div Translat & Regenerat MedIssue Date
2018-01-01
Metadata
Show full item recordPublisher
SPANDIDOS PUBL LTDCitation
Zhang, Z., Wang, J., Zeng, X., Li, D., Ding, M., Guan, R. ... Lu, W. (2018). Two‑stage study of lung cancer risk modification by a functional variant in the 3'‑untranslated region of SMAD5 based on the bone morphogenetic protein pathway. Molecular and Clinical Oncology, 8, 38-46. https://doi.org/10.3892/mco.2017.1490Journal
MOLECULAR AND CLINICAL ONCOLOGYRights
© Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Increasing evidence supports a key role for the bone morphogenetic protein (BMP) signaling pathway in lung vasculogenesis and angiogenesis. Genetic variations in BMP genes have been found to be correlated with cancer risk. In particular, the mutation in the 3'-untranslated region of BMPs may significantly affect gene function, leading to cancer susceptibility. The aim of the present study was to determine whether genetic variations in the components of the BMP family are associated with lung cancer risk. A total of 314 tag single-nucleotide polymorphisms were identified in 18 genes, which are considered to either compose or regulate BMPs, and their association with lung cancer risk was evaluated in a two-stage case-control study with 4,680 cases and controls. A consistently significant association of SMAD5 rs12719482 with elevated lung cancer risk was observed in the three types of sources of populations (adjusted additive model in the combined population: Odds ratio=1.32, 95% confidence interval: 1.16-1.51). The lung cancer risk statistically significantly increased with the increasing number of variant alleles of SMAD5 rs12719482 in a dose-dependent pattern (P for trend=4.9×10-5). Consistent evidence was identified for a significant interaction between the rs12719482 and cigarette smoking, performed as either a continuous or discrete variable. These findings indicated that SMAD5 rs12719482 may be a possible candidate marker for susceptibility to lung cancer in the Chinese population.Note
6 month embargo; published online: 6 November 2017ISSN
2049-9450PubMed ID
29387395Version
Final published versionSponsors
National Natural Science Foundation of China [81520108001, 81220108001, 81170052]; 973 Key Scheme of China [2015CB553406]; National Key Research and Development Project [2016YFC0903700]; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2014); Guangdong Province Universities and Colleges Key Grant for Innovative Research [cxzd1142]; Guangzhou Municipal Research Project [201607020030]; Guangzhou Department of Education Innovative Team [13C08]; Guangzhou Department of Education Yangcheng Scholarship [12A001S]; Guangdong Natural Science Foundation [2016A030313593]; Guangzhou Municipal University Research Projects [1201430298]Additional Links
https://www.spandidos-publications.com/10.3892/mco.2017.1490ae974a485f413a2113503eed53cd6c53
10.3892/mco.2017.1490
Scopus Count
Collections
Except where otherwise noted, this item's license is described as © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Related articles
- Identification of TRPCs genetic variants that modify risk for lung cancer based on the pathway and two-stage study.
- Authors: Zhang Z, Wang J, He J, Zeng X, Chen X, Xiong M, Zhou Q, Guo M, Li D, Lu W
- Issue date: 2016 Sep
- Bone morphogenetic proteins.
- Authors: Chen D, Zhao M, Mundy GR
- Issue date: 2004 Dec
- Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export.
- Authors: Wang H, Jin G, Wang H, Liu G, Qian J, Jin L, Wei Q, Shen H, Huang W, Lu D
- Issue date: 2009 Feb 1
- Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels.
- Authors: Bosman EA, Lawson KA, Debruyn J, Beek L, Francis A, Schoonjans L, Huylebroeck D, Zwijsen A
- Issue date: 2006 Sep
- The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer-A potential therapeutic target.
- Authors: Peng J, Yoshioka Y, Mandai M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J, Kharma B, Murakami R, Abiko K, Murphy SK, Konishi I
- Issue date: 2016 Apr