Metabolome Changes In The Blood During Dehydration In Aerobic Exercise

Abstract

Background: Dehydration has detrimental effects on exercise performance seen starting around a 1% body mass loss (BML). A past study found that Kona deep-ocean mineral water provided better rehydration compared to water and a carbohydrate sports drink (Keen et al., 2016). With this knowledge, a total metabolomic analysis will be done to determine what metabolites play a role in hydration, ultimately to be used to decrease or prevent dehydration in aerobic exercise. Findings: A literary analysis of plasma metabolomic changes in aerobic exercise cross-referenced with dehydration was completed and will be used to check the validity of protocol and expected values in the corresponding laboratory. Plasma cortisol, catecholamines, lactate, potassium, alanine, glutamate, and sodium levels all increased. Glucose decreased with longer duration activity with hydration state not playing a large role, urea levels also decreased with hypohydration but were not affected by exercise intensity, and AMP levels in the muscle increased but to the same level regardless of hydration state. Conclusions: With a better understanding of the changes of key metabolites in the blood, these findings can go towards creating a more efficient source of hydration to either prevent the effects of dehydration or minimize them.