PublisherThe University of Arizona.
AbstractThe purpose of this thesis was to discuss the biological and clinical components of sexual differentiation. Although it is genetic, mutations leading to disorders of sex development (DSD) can be of great concern to patients and their families. The proposed pathway of sexual determination in combination with the known genes and disorders of sex development help provide necessary information to genetic counselors and medical professionals on how to approach a patient that has been diagnosed with a DSD, while keeping in mind potential psychosexual outcomes. This thesis provides a new look at the proposed pathway as well as information regarding the genes involved in sex differentiation and disorders of sex development. It also provides insight into genetic testing, clinical management, and psychosexual outcomes for patients diagnosed with a DSD.