Show simple item record

dc.contributor.advisorSchroeder, Joyce
dc.contributor.authorMalecha, Lindsey Catherine
dc.creatorMalecha, Lindsey Catherine
dc.date.accessioned2019-06-13T03:58:11Z
dc.date.available2019-06-13T03:58:11Z
dc.date.issued2019
dc.identifier.urihttp://hdl.handle.net/10150/632835
dc.description.abstractThe overexpression of cyclin-D1 has been shown previously to be a factor in regulating a shallow state of quiescence in breast cancer cells. This is thought to be due to the increased trafficking of EGFR, a cyclin-D1 transcription cofactor, to the nucleus as a result of interaction with MUC1.¹’² This study sought to create an accurate in vitro model of quiescent behavior and its regulation mechanism that can then be manipulated to find ways to modulate quiescence. In collaboration with Léa Boden, a model was identified for MDA-MB-468 triple negative breast cancer cells³. In MDA-MB-468 cells, shMUC1 variants had lower levels of cyclin-D1 expression and lower levels of chromatin-bound EGFR than the shCTL variants, thus supporting that MUC1 interaction affects EGFR trafficking to the nucleus.
dc.language.isoen
dc.publisherThe University of Arizona.
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
dc.titleCyclin-D1 And MUC1 Mediated Control Of Breast Cancer Cell Quiescence
dc.typetext
dc.typeElectronic Thesis
thesis.degree.grantorUniversity of Arizona
thesis.degree.disciplineHonors College
thesis.degree.disciplineBiology
thesis.degree.nameB.S.
refterms.dateFOA2019-06-13T03:58:11Z


Files in this item

Thumbnail
Name:
azu_etd_hr_2019_0132_sip1_m.pdf
Size:
1.931Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record