Targeting Cortisol And Metabolites In Human Eccrine Sweat As Biomarkers For Mental Health
AuthorKubacki, Marisa Taylor
AdvisorSternberg, Esther M.
MetadataShow full item record
PublisherThe University of Arizona.
AbstractStudies have found that the use of human eccrine sweat for tracking human biomarkers, such as cortisol and downstream cortisol metabolites, was a viable, non-invasive option that yielded similar results to plasma cortisol (Jia et al., 2016, p. 2053). These biomarkers were found to be stable in human eccrine sweat and that their production was due, in part, to stress-related physiological events (Runyon, et al., 2019, p. 1). Also, patients with a current anxiety disorder displayed significantly higher awakening cortisol levels (p = 0.02) than those without a diagnosed anxiety disorder (Vreeburg, et al., 2010, p. 340). These findings indicate that cortisol levels found in human eccrine sweat can be used as a potential quantitative indicator of a mental health disorder with cortisol and metabolite concentrations in sweat being used to aid in the research and advancement of the understanding of underlying mechanisms. This is a preliminary study that will further the research currently being done on sweat collection systems and research the connection between cortisol and anxiety by identifying any correlations in selected target biomarkers found in eccrine sweat (such as cortisol, cortisone, and cortisol metabolites) and differing anxiety levels as indicated through the State-Trait Anxiety Index (STAI).