The Magnitude Of NK Cell Mobilization Is Associated With Plasma Epinephrine In Response To Steady-State Aerobic Exercise
AuthorLynn, Cassandra Amalia
AdvisorSimpson, Richard J.
MetadataShow full item record
PublisherThe University of Arizona.
AbstractThe objective of our research was to identify any demographical or physiological differences between participants split into high and low groups based on median NK cell deployment that might leave them less likely to receive exercise-induced cancer benefits. We hypothesized that ß-adrenergic receptor sensitivity would be positively correlated with the amount of epinephrine secreted during exercise, resulting in greater lymphocyte mobilization with greater catecholamine secretion. 18 participants performed steady-state exercise on a stationary leg cycling ergometer at workloads determined to be 10% above their individually determined lactate threshold (LT). Baseline demographic characteristics and physiological values collected during the experiment were compared across high and low NK cell mobilizers. The results show that out of all characteristics accounted for in this study, epinephrine release post-exercise was the only statistically significant variable (p<0.05). Low NK cell deployers released less amounts of epinephrine (mean=0.101 ng/mL) during exercise than high NK cell deployers (mean=0.188 ng/mL). This difference in epinephrine release post-exercise may be explained by factors related to obesity, errors in calculating lactic threshold (LT), or perhaps even psychological perception of stress, but the reasons still remain unclear.