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    Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations

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    Author
    Daya, Michelle
    Rafaels, Nicholas
    Brunetti, Tonya M
    Chavan, Sameer
    Levin, Albert M
    Shetty, Aniket
    Gignoux, Christopher R
    Boorgula, Meher Preethi
    Wojcik, Genevieve
    Campbell, Monica
    Vergara, Candelaria
    Torgerson, Dara G
    Ortega, Victor E
    Doumatey, Ayo
    Johnston, Henry Richard
    Acevedo, Nathalie
    Araujo, Maria Ilma
    Avila, Pedro C
    Belbin, Gillian
    Bleecker, Eugene
    Bustamante, Carlos
    Caraballo, Luis
    Cruz, Alvaro
    Dunston, Georgia M
    Eng, Celeste
    Faruque, Mezbah U
    Ferguson, Trevor S
    Figueiredo, Camila
    Ford, Jean G
    Gan, Weiniu
    Gourraud, Pierre-Antoine
    Hansel, Nadia N
    Hernandez, Ryan D
    Herrera-Paz, Edwin Francisco
    Jiménez, Silvia
    Kenny, Eimear E
    Knight-Madden, Jennifer
    Kumar, Rajesh
    Lange, Leslie A
    Lange, Ethan M
    Lizee, Antoine
    Maul, Pissamai
    Maul, Trevor
    Mayorga, Alvaro
    Meyers, Deborah
    Nicolae, Dan L
    O'Connor, Timothy D
    Oliveira, Ricardo Riccio
    Olopade, Christopher O
    Olopade, Olufunmilayo
    Qin, Zhaohui S
    Rotimi, Charles
    Vince, Nicolas
    Watson, Harold
    Wilks, Rainford J
    Wilson, James G
    Salzberg, Steven
    Ober, Carole
    Burchard, Esteban G
    Williams, L Keoki
    Beaty, Terri H
    Taub, Margaret A
    Ruczinski, Ingo
    Mathias, Rasika A
    Barnes, Kathleen C
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    Affiliation
    Univ Arizona, Dept Med, Coll Med
    Issue Date
    2019-02-20
    
    Metadata
    Show full item record
    Publisher
    NATURE PUBLISHING GROUP
    Citation
    Daya, M., Rafaels, N., Brunetti, T. M., Chavan, S., Levin, A. M., Shetty, A., ... & Vergara, C. (2019). Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nature communications, 10(1), 880.
    Journal
    NATURE COMMUNICATIONS
    Rights
    © The Author(s) 2019.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.
    Note
    Open access journal
    ISSN
    2041-1723
    PubMed ID
    30787307
    DOI
    10.1038/s41467-019-08469-7
    Version
    Final published version
    Additional Links
    https://www.nature.com/articles/s41467-019-08469-7
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-019-08469-7
    Scopus Count
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    UA Faculty Publications

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