Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations
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Daya, MichelleRafaels, Nicholas
Brunetti, Tonya M
Chavan, Sameer
Levin, Albert M
Shetty, Aniket
Gignoux, Christopher R
Boorgula, Meher Preethi
Wojcik, Genevieve
Campbell, Monica
Vergara, Candelaria
Torgerson, Dara G
Ortega, Victor E
Doumatey, Ayo
Johnston, Henry Richard
Acevedo, Nathalie
Araujo, Maria Ilma
Avila, Pedro C
Belbin, Gillian
Bleecker, Eugene
Bustamante, Carlos
Caraballo, Luis
Cruz, Alvaro
Dunston, Georgia M
Eng, Celeste
Faruque, Mezbah U
Ferguson, Trevor S
Figueiredo, Camila
Ford, Jean G
Gan, Weiniu
Gourraud, Pierre-Antoine
Hansel, Nadia N
Hernandez, Ryan D
Herrera-Paz, Edwin Francisco
Jiménez, Silvia
Kenny, Eimear E
Knight-Madden, Jennifer
Kumar, Rajesh
Lange, Leslie A
Lange, Ethan M
Lizee, Antoine
Maul, Pissamai
Maul, Trevor
Mayorga, Alvaro
Meyers, Deborah
Nicolae, Dan L
O'Connor, Timothy D
Oliveira, Ricardo Riccio
Olopade, Christopher O
Olopade, Olufunmilayo
Qin, Zhaohui S
Rotimi, Charles
Vince, Nicolas
Watson, Harold
Wilks, Rainford J
Wilson, James G
Salzberg, Steven
Ober, Carole
Burchard, Esteban G
Williams, L Keoki
Beaty, Terri H
Taub, Margaret A
Ruczinski, Ingo
Mathias, Rasika A
Barnes, Kathleen C
Affiliation
Univ Arizona, Dept Med, Coll MedIssue Date
2019-02-20
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NATURE PUBLISHING GROUPCitation
Daya, M., Rafaels, N., Brunetti, T. M., Chavan, S., Levin, A. M., Shetty, A., ... & Vergara, C. (2019). Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nature communications, 10(1), 880.Journal
NATURE COMMUNICATIONSRights
© The Author(s) 2019.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find strong evidence for association at four previously reported asthma loci whose discovery was driven largely by non-African populations, including the chromosome 17q12-q21 locus and the chr12q13 region, a novel (and not previously replicated) asthma locus recently identified by the Trans-National Asthma Genetic Consortium (TAGC). An additional seven loci reported by TAGC show marginal evidence for association in CAAPA. We also identify two novel loci (8p23 and 8q24) that may be specific to asthma risk in African ancestry populations.Note
Open access journalISSN
2041-1723PubMed ID
30787307Version
Final published versionAdditional Links
https://www.nature.com/articles/s41467-019-08469-7ae974a485f413a2113503eed53cd6c53
10.1038/s41467-019-08469-7
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