How does Fetal Autopsy after Pregnancy Loss or Termination for Anomalies and other Complications Change Recurrence Risk?
AffiliationUniv Arizona, Dept Obstet & Gynecol
MetadataShow full item record
PublisherTHIEME MEDICAL PUBL INC
CitationCassidy, A., Herrick, C., Norton, M. E., Ursell, P. C., Vargas, J., & Kerns, J. L. (2019). How does Fetal Autopsy after Pregnancy Loss or Termination for Anomalies and other Complications Change Recurrence Risk?. American Journal of Perinatology Reports, 9(01), e30-e35.
RightsCopyright © 2019 by Thieme Medical
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractHistorically, fetal autopsy was common after terminations for anomalies. Previous studies report that fetal autopsy confirms ultrasound findings in the majority of cases. This study aims to examine correlation between prenatal and autopsy diagnoses at University of California, San Francisco (UCSF) and evaluate whether autopsy adds diagnostic information, specifically information that changes risk of recurrence for future pregnancies. We conducted a retrospective chart review of all fetal autopsies performed at UCSF between 1994 and 2009. Prenatal diagnosis was compared with autopsy diagnosis; for cases where there was a change in diagnosis, an MFM (maternal-fetal medicine specialist) reviewed the case to assign risk of recurrence before and after autopsy. Overall, there was concordance between prenatal diagnosis and autopsy diagnosis in greater than 91.7% of cases. Autopsy added information that resulted in a change in recurrence risk in 2.3% of cases ( n = 9). For the vast majority of cases, there is agreement between prenatal and autopsy diagnosis after pregnancy loss or termination for fetal anomalies. Only a small percentage of autopsies change recurrence risk. This may be useful when counseling women about method of termination and when counseling couples about whether to have an autopsy.
NoteOpen access journal
VersionFinal published version
SponsorsUCSF Dean's Office Medical Student Research Program
- Critical evaluation of elective termination of pregnancy in a tertiary fetal medicine center during 43 months: correlation of prenatal diagnosis findings and postmortem examination.
- Authors: Ramalho C, Matias A, Brandão O, Montenegro N
- Issue date: 2006 Nov
- The role of autopsy following pregnancy termination for fetal abnormality.
- Authors: Dickinson JE, Prime DK, Charles AK
- Issue date: 2007 Dec
- Evaluation of prenatally diagnosed structural congenital anomalies.
- Authors: Gagnon A, GENETICS COMMITTEE.
- Issue date: 2009 Sep
- Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester.
- Authors: Akgun H, Basbug M, Ozgun MT, Canoz O, Tokat F, Murat N, Ozturk F
- Issue date: 2007 May
- Autopsy after termination of pregnancy for fetal anomaly: retrospective cohort study.
- Authors: Boyd PA, Tondi F, Hicks NR, Chamberlain PF
- Issue date: 2004 Jan 17